| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we investigated the effect of p53 signal transduction targeting agent on oral cancer cells and its mechanism. Treatment of human oral cancer cell lines with p53 signal transduction targeting agents (RITA, CP-31398, PRIMA-1) suppressed cell proliferation and also induced apoptosis. In particular, RITA suppressed MDM2, which acts on p53 suppression, and activated p53. Furthermore, the expression of BAX, which is involved in p53-dependent apoptosis, was increased, which indicates that RITA suppresses MDM2 activity in oral cancer cells, stabilizes p53, and activates p53 signaling pathway to induce apoptosis.
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