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Effects of local anesthetics on the wound healing process by increasing nerve growth factor expression in fibroblasts

Research Project

Project/Area Number 17K17239
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Matsumura Tomoka  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (40527066)

Project Period (FY) 2017-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯科麻酔学 / 局所麻酔薬 / 線維芽細胞 / 創傷治癒 / 局所麻酔 / アポトーシス / 筋線維芽細胞 / 神経成長因子 / 歯学 / 細胞・組織
Outline of Final Research Achievements

Cultured human fibroblasts were treated with various concentrations of lidocaine, and changes in nerve growth factor (NGF) expression, cell proliferative ability, cell morphology, and cell migration ability were observed over time after administration. In the group treated with high concentrations of lidocaine, changes in fibroblast morphology were observed after administration, and inhibition of cell proliferation was observed. Lidocaine administration to myofibroblasts involved in scar formation inhibited cell proliferation in a dose-dependent manner, and apoptosis induction was observed at high concentrations. The results suggest that lidocaine may be useful in controlling good wound healing in parallel with perioperative pain management.

Academic Significance and Societal Importance of the Research Achievements

局所麻酔薬は過去の研究により細胞増殖抑制やアポトーシスの誘導などが報告されているが、実際の臨床で局所麻酔薬投与による創傷治癒の遅延などはほとんど見られない。線維化による術後創傷瘢痕やケロイドは難治性とされている。線維芽細胞および筋線維芽細胞のアポトーシスを誘導する抗癌剤は治療の候補であるが、副作用が強く、実用化には至っていない。本研究は、最も一般的な局所麻酔薬であるリドカインを、皮膚線維症の治療におけるドラッグリポジショニングとして、他の臓器の線維症治療にも使用できる可能性を示した。

Report

(8 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2023 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] 台湾 国泰総合病院(その他の国・地域)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Considerations for Satisfactory Sedation during Dental Implant Surgery2023

    • Author(s)
      Ito Takaya、Utsumi Nozomi、Baba Yukiko、Matsumura Tomoka、Wakita Ryo、Maeda Shigeru
    • Journal Title

      Journal of Personalized Medicine

      Volume: 13 Issue: 3 Pages: 461-461

    • DOI

      10.3390/jpm13030461

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined Use of a Gum Elastic Bougie and Video Laryngoscopy for Intubating a Patient With an Unexpected Laryngeal Papilloma2020

    • Author(s)
      Ikeda Nanako、Matsumura Tomoka、Kono Haruna、Baba Yukiko、Hanaoka Miho、Fukayama Haruhisa
    • Journal Title

      Anesthesia Progress

      Volume: 67 Issue: 4 Pages: 230-232

    • DOI

      10.2344/anpr-67-03-01

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sugammadex-induced anaphylaxis involving sudden onset of severe abdominal pain2019

    • Author(s)
      Matsumura Tomoka、Mitani Shigeki、Fukayama Haruhisa
    • Journal Title

      Journal of Clinical Anesthesia

      Volume: 57 Pages: 119-120

    • DOI

      10.1016/j.jclinane.2019.04.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difficult Nasal Intubation Using Airway Scope? for a Child With Large Tumor2018

    • Author(s)
      Matsumura Tomoka、Suzuki Chihiro、Kubota Kazumasa、Minakuchi Shunsuke、Fukayama Haruhisa
    • Journal Title

      Anesthesia Progress

      Volume: 65 Issue: 4 Pages: 251-254

    • DOI

      10.2344/anpr-65-04-08

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 甲状腺癌の既往の患者に対し予期せぬ挿管困難が生じた1例2018

    • Author(s)
      阿部 彩由美, 脇田 亮, 阿部 桂子, 松村 朋香, 深山 治久
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 4 Pages: 65-67

    • NAID

      130006707973

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] The effect of lidocaine on cell proliferation of myofibroblasts2023

    • Author(s)
      Tomoka Matsumura, Sayaka Asano, Shigeru Maeda
    • Organizer
      14th The Federation of Asian Dental Anesthesiology Societies (FADAS)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋電図式および加速度感知式筋弛緩モニターの使用によるスガマデクス投与の比較2023

    • Author(s)
      高橋 賢, 馬場 有希子, 島田 奈緒美, 鈴木 千裕, 佐藤 裕, 伊藤 孝哉, 松村 朋香, 脇田 亮, 前田 茂
    • Organizer
      第51回 日本歯科麻酔学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Lidocaine suppresses cell proliferation and induces apoptosis of myofibroblasts2021

    • Author(s)
      Tomoka Matsumura, Shigeru Maeda
    • Organizer
      Neuroscience 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 補助人工心臓埋入患者の歯科治療時における全身管理経験2021

    • Author(s)
      佐藤 裕,松村 朋香,脇田 亮
    • Organizer
      第48 回日本歯科麻酔学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 静脈内鎮静法下に行った気管切開後に発生した縦隔気腫の1 例.2021

    • Author(s)
      髙橋 賢,松村 朋香,中島 淳,安部 勇志,船山 拓也,脇田 亮,深山 治久.
    • Organizer
      第48 回日本歯科麻酔学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 注意欠如・多動性障害(ADHD)小児の口腔外科再建手術術後にデクスメデトミジンによる鎮静を行った一症例2019

    • Author(s)
      花岡 美穂 , 松村 朋香 , 阿部 彩由美 , 船山 拓也 , 安部 勇志 , 深山 治久
    • Organizer
      日本歯科麻酔学会 学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 全身麻酔後に複数回おきた頻脈性不整脈に対するValsalva法により高度徐脈が生じた1例2019

    • Author(s)
      千葉 真子 , 船山 拓也 , 阿保 綱孝 , 松村 朋香 , 脇田 亮 , 深山 治久
    • Organizer
      日本歯科麻酔学会 学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 気管挿管時に喉頭腫瘤が発見された一症例2018

    • Author(s)
      河野晴奈 松村朋香 馬場有希子 深山治久
    • Organizer
      第35回 関東臨床歯科麻酔懇話会
    • Related Report
      2018 Research-status Report
  • [Presentation] Sugammadex induced anaphylactic shock noticed when intense urge to urinate2018

    • Author(s)
      Tomoka MATSUMURA, Shigeki MITANI, Haruhisa FUKAYAMA
    • Organizer
      IFDAS 2018
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2025-01-30  

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