| Project/Area Number |
17K17247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 口腔前癌病変 / 発癌 / 白板症 / 口腔扁平上皮癌 / 早期発見 / 病理診断 / マクロファージ / 新規治療法 / 新規病理診断法 / IL-10 / CD163 |
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| Outline of Final Research Achievements |
To investigate the role of macrophages in oral carcinogenesis, we conducted immunohistochemical analyses with tongue leukoplakia samples and in vitro assays with human oral keratinocytes and THP-1 human monocytic leukemia cells. Our results indicated that IL-10 induced by CD163-positive macrophages may contribute to the development of tongue leukoplakia via immunosuppression. Furthermore, it is showed that the distribution of CD163-positive macrophages differs during oral carcinogenesis. It was identified the evaluation of the distribution of CD163-positive macrophages is potentially useful for preoperative biopsy diagnosis of tongue leukoplakia.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで口腔の発癌段階におけるマクロファージの役割に関する報告は少数であったが、本研究によりCD163を発現するマクロファージが腫瘍免疫回避を介し生物学的なプロモーターとして関与する可能性が示された。また、発癌過程においてCD163陽性マクロファージの局在が変化することを明らかにし、 本結果が日常の病理診断(術前局所生検)に応用できる可能性も見出した。
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