| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
When the anticancer drug docetaxel and the vitamin E derivative γ-tocotrienol were used in combination with the oral squamous cell line B88 cells, a remarkable antitumor effect was observed. In this study, we focused on the transcription factor NF-κB and examined its antitumor effect. Activation of NF-κB was observed by docetaxel, but activation of NF-κB was suppressed by the combined use of γ-tocotrienol. It was considered that the combined use induces apoptosis by suppressing the expression of the apoptosis-suppressing protein controlled by NF-κB and increasing the expression of the apoptosis-related protein.
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