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Development of Dormancy Therapy for adenoid cyst cancer through CD82-specific miRNA

Research Project

Project/Area Number 17K17259
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

Chigita Satomi  九州大学, 大学病院, 医員 (10711179)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腺様嚢胞癌 / miRNA / 腺様嚢胞癌細胞 / CD82 / 腺葉嚢胞癌 / 癌転移抑制
Outline of Final Research Achievements

miR-203 thought to be anti-oncomiR regulates KAI1/CD82(CD82) through Wnt signaling pathway, and adenoid cystic carcinoma cells transfection with miR-203 mimics analyzed a change of the malignant character.
We previously isolated the highly metastatic and tumorigenic ACC subline ACCS-M from nonmetastatic (0% incidence) and low tumorigenic (22.2% incidence) parental ACCS cells. ACCS-M exhibited high tumorigenicity (100% incidence), high frequency of spontaneous metastasis to submandibular lymph nodes (100% incidence). Transfection with miR-203 and miR-203 inhibitor to the ACCS and ACCS-M suggests controlling cellular proliferation and cellular infiltration ability. We examined clinical drug delivery system to apply the mechanism.

Academic Significance and Societal Importance of the Research Achievements

唾液腺悪性腫瘍の一つである腺様嚢胞癌は、強い局所浸潤能と遠隔転移能を有するが、発育が緩慢なものも多い。よって、担癌状態で比較的長期に生存する患者も少なくないが、やはり現在の所、その治療は外科的切除に頼るしかなく、他にエビデンスが確立された治療法は無い。これは、強い局所浸潤能や遠隔転移能を制御できれば10年、20年といった長期の生存の可能性を意味し、口腔癌の中ではそれが可能な唯一の癌腫であるとも言える。そこで本研究ではテトラスパニンCD82/KAI1(CD82)やその関連microRNA(miRNA)を用い、長期担癌生存、いわゆる『Dormancyを目指した腺様嚢胞癌治療の開発』を目的とした。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results)

  • [Presentation] 線維素性唾液管炎と診断した3例 Three cases of sialodochitis fibrinosa2017

    • Author(s)
      千北さとみ、大山順子、蔵原慎一、石井広太郎、秋本直柔、上妻亜也子、長野公喜、清島保、清水真弓、森悦秀
    • Organizer
      第62回 口腔外科学会総会・学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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