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Circulating microRNA Panel as a Potential Novel Biomarker for Oral Squamous Cell Carcinoma Diagnosis

Research Project

Project/Area Number 17K17280
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

Nakamura Kodai  鹿児島大学, 鹿児島大学病院, 医員 (90783506)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsmicroRNA / 腫瘍マーカー / 口腔癌 / 液体生検 / リキッドバイオプシー / バイオマーカー / 口腔外科学一般 / ctDNA / miRNA
Outline of Final Research Achievements

A lack of reliable biomarkers for oral squamous cell carcinoma (OSCC) poses a major clinical issue. The sensitivity and specificity of classical serum tumor markers, such as the squamous cell carcinoma antigen (SCC-Ag), are quite poor, especially for early detection. This study aimed to identify specific serum miRNAs potentially serving as OSCC biomarkers. The expression levels of candidate miRNAs in serum samples from 40 OSCC patients and 40 healthy controls were quantitatively analyzed via microarray and reverse transcription PCR (RT-PCR) analyses. To enhance the accuracy of detection, we used Fisher’s linear discriminant analysis to establish a diagnostic model that incorporated a combination of selected miRNAs.

Academic Significance and Societal Importance of the Research Achievements

口腔癌の非侵襲的検査法は実用化されておらず、現状では、確定診断のためには組織を切除する「生検」しか方法がない(この方法は多くの合併症を有する)。また現状の口腔癌検診は専門家の診察によるものでコストパフォーマンスが低く、大規模検診には不向きである。口腔癌には、大腸癌の便潜血検査や胃癌のバリウム検査などのような、比較的良好な感度と特異度を有する1次検診法が存在しない。よって本研究結果は、口腔癌の新規診断法・新規検診法の技術基盤となる可能性がある。本技術研究開発を進めて行く目標として「臨床現場即時検査(POCT)タイプの装置の開発」および「口腔癌腫瘍マーカーとしての保険収載」を見据えている。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2021 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Circulating microRNA Panel as a Potential Novel Biomarker for Oral Squamous Cell Carcinoma Diagnosis2021

    • Author(s)
      Kodai Nakamura, Naomi Hiyake, Tomofumi Hamada, Seiya Yokoyama, Kazuki Mori, Kouta Yamashiro, Mahiro Beppu, Yasuaki Sagara, Yoshiaki Sagara, Tsuyoshi Sugiura
    • Journal Title

      Cancers

      Volume: 13(3) Issue: 3 Pages: 449-449

    • DOI

      10.3390/cancers13030449

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規血清microRNAを用いた口腔扁平上皮癌診断アルゴリズムの構築2019

    • Author(s)
      中村康大
    • Organizer
      第73回日本口腔科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Novel serum microRNAs specific for oral squamous cell carcinoma: its usefulness for early detection2019

    • Author(s)
      Koudai Nakamura
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規血清microRNAを用いた口腔扁平上皮癌診断アルゴリズムの構築2019

    • Author(s)
      中村 康大
    • Organizer
      第73回NPO法人日本口腔科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口腔扁平上皮癌の検出に有用な血清microRNAの検討2018

    • Author(s)
      中村 康大
    • Organizer
      南九州腫瘍研究会  第29回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 口腔扁平上皮癌に特異的な新規血清microRNA: 早期発見への有用性の検討2017

    • Author(s)
      中村 康大
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 口腔癌判定装置、口腔癌判定方法、プログラム及び口腔癌判定キット2018

    • Inventor(s)
      中村康大
    • Industrial Property Rights Holder
      中村康大
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 口腔癌判定装置、口腔癌判定方法、プログラム及び口腔癌判定キット2018

    • Inventor(s)
      中村康大
    • Industrial Property Rights Holder
      中村康大
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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