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Molecular analysis of infectious spreading mechanisms of children's pharyngitis by group A strptococcus

Research Project

Project/Area Number 17K17317
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNiigata University

Principal Investigator

Kurosawa Mie  新潟大学, 医歯学系, 助教 (70792282)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小児 / 咽頭炎 / A群レンサ球菌 / 細菌毒素CF / 付着・侵入 / 咽頭上皮細胞 / 付着侵入因子
Outline of Final Research Achievements

Group A strptococcus is a bacterium that causes children's pharyngitis, and recently, the number of patient-reported has increased rapidly in Japan. Group A strptococcus secretes CAMP factor. In this study, we revealed that CAMP factor promoted streptococcal adhesion and invasion in pharyngeal epithelial cells. CAMP factor initially localized on the cell membranes and then became internalized in the cytosol following bacterial infection. Additionally, CAMP factor activated signaling pathway that involved in phagocytosis.

Academic Significance and Societal Importance of the Research Achievements

現在,A群レンサ球菌による咽頭炎予防のためのワクチンは実用化されていない.本申請研究は,A群レンサ球菌の産生する細菌毒素CFにより本菌の咽頭上皮細胞への付着・侵入が亢進することで本菌の組織内侵入が惹起され,咽頭炎発症の一助となることが示唆された.本結果より,細菌毒素CFを抗原とする咽頭炎予防ワクチン開発の可能性が示された.本申請研究の成功を通じて,小児における咽頭炎発症ならびに重症化の予防研究へ発展させ,歯科学が主導となり口腔関連感染症の医療費削減にも寄与し,社会的な貢献を果たしたいと考えている.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells.2018

    • Author(s)
      Kurosawa M, Oda M, Domon H, Isono T, Nakamura Y, Saitoh I, Hayasaki H, Yamaguchi M, Kawabata S, Terao Y.
    • Journal Title

      Microbiol Immuno

      Volume: 62 Issue: 10 Pages: 617-623

    • DOI

      10.1111/1348-0421.12647

    • NAID

      40021702611

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway2018

    • Author(s)
      Kurosawa Mie、Oda Masataka、Domon Hisanori、Isono Toshihito、Nakamura Yuki、Saitoh Issei、Hayasaki Haruaki、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Microbes Infect

      Volume: 20 Issue: 1 Pages: 9-18

    • DOI

      10.1016/j.micinf.2017.09.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Streptococcus pyogenes CAMP factor Promotes Bacterial Adhesion and Invasion in Pharyngeal Epithelial Cells without Serum2018

    • Author(s)
      1)Kurosawa M, Oda M, Domon H, Saitoh I, Hayasaki H, Terao Y
    • Organizer
      International collaborative symposium on development of human resources in practical oral health and treatment
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pyogenesの咽頭上皮細胞株への付着・侵入におけるCAMP factorとPI3K/Akt経路との関連2017

    • Author(s)
      1)黒澤美絵,小田真隆,土門久哲,齊藤一誠,早崎治明,寺尾 豊
    • Organizer
      第49回レンサ球菌研究会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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