| Project/Area Number |
17K17326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Ohara Yukari 広島大学, 医歯薬保健学研究科(歯), 専門研究員 (80634469)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 小児齲蝕 / 齲蝕 / 小児歯科 / streptococcus mutans |
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| Outline of Final Research Achievements |
Dental caries is a most popular disease in an pediatric dental practice. It is important that suitable caries prophylaxis is established individually with comprehending the pathogenicity character of the caries pathogen which an individual child holds.
Streptococcus mutans (S.mutans) which is a main pathogen of the dental caries suffers effects by intraoral various environmental changes. For establishment of the effective dental caries prophylaxis that the cariogenicity is reduced, It was searched for effective prophylaxis from a gene expression change with the material included fluoride and et al which inhibited enzyme activity of S.mutans.
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| Academic Significance and Societal Importance of the Research Achievements |
世界的に齲蝕は減少傾向と言われているが、本邦の現状として小児歯科診療室を訪れる重症齲蝕の低年齢児あるいは発達障害児は少なくなく、齲蝕罹患について二極化が認められている。齲蝕の原因としては食生活（糖分摂取）・歯質・細菌と多因子により罹患するが、本研究はその原因因子のうちの細菌をターゲットとした。個人が保有する齲蝕原因菌の病原性を把握したうえで個々に適した齲蝕予防法を確立することは学術的にも社会的にも重要で意義あることである。
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