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Elucidation of the influence of periodontal pathogen infection on the association between diabetic myocardial disease and selective autophagy

Research Project

Project/Area Number 17K17347
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Shiheido Yuka  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (60791853)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯周病原細菌 / 糖尿病性心筋障害 / 選択的オートファジー / 歯周病 / 糖尿病 / 心筋梗塞 / 心筋障害
Outline of Final Research Achievements

Recently, it has been pointed out that the suppression of autophagy was also involved in myocardial disease due to diabetes. We demonstrated that infection with a periodontal pathogen induced cardiac rupture after myocardial infarction due to the suppression of mitochondrial selective autophagy (mitophagy). The purpose of this study was to elucidate the pathogenesis of myocardial disfunction due to diabetes and infection of a periodontal pathogen from the viewpoint of autophagy dysregulation. Our results suggested that the infection of a periodontal pathogen may deteriorate myocardial disfunction due to diabetes through suppression of autophagy.

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、主要な歯周病原細菌であるPorphyromonas gingivalisの感染がオートファジー制御機構を阻害することで、糖尿病による心筋障害をさらに悪化させている可能性が示唆された。このことから、オートファジー制御機構をコントロールすることで、歯周病による糖尿病性心筋障害への影響を抑制できる可能性があることが明らかとなった。
本研究成果を応用することにより、将来的にはオートファジー制御機構をターゲットとした新規治療法の確立や創薬開発へと発展させることが期待できる。さらに歯周病予防の重要性を唱えるエビデンスに新たな一石を投じることができる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Periodontal condition in Japanese coronary heart disease patients - A comparison between coronary and non-coronary heart diseases.2019

    • Author(s)
      Aoyama Norio, Kobayashi Naho, Hanatani Tomoya, Ashigaki Norihiko, Yoshida Asuka, Shiheido Yuka, Sato Hiroki, Takamura Chisato, Yoshikawa Shunji, Matsuo Katsuhiko, Izumi Yuichi, Isobe Mitsuaki.
    • Journal Title

      Journal of Periodontal Research

      Volume: 54 Pages: 259-265

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis2018

    • Author(s)
      Tamura Natsuko、Maejima Yasuhiro、Matsumura Takayoshi、Vega Rick B.、Amiya Eisuke、Ito Yusuke、Shiheido-Watanabe Yuka、Ashikaga Takashi、Komuro Issei、Kelly Daniel P.、Hirao Kenzo、Isobe Mitsuaki
    • Journal Title

      Circulation: Genomic and Precision Medicine

      Volume: 11 Issue: 10

    • DOI

      10.1161/circgen.118.002296

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased Oral Porphyromonas gingivalis Prevalence in Cardiovascular Patients with Uncontrolled Diabetes Mellitus.2018

    • Author(s)
      Aoyama Norio, Suzuki Jun-ichi, Kobayashi Naho, Hanatani Tomoya, Ashigaki Norihiko, Yoshida Asuka, Shiheido Yuka, Sato Hiroki, Izumi Yuichi, Isobe Mitsuaki.
    • Journal Title

      International Heart Journal

      Volume: 59

    • NAID

      130007428176

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic effects of HMG-CoA reductase inhibitor and angiotensin II receptor blocker on load-induced heart failure2018

    • Author(s)
      Ito Yusuke、Maejima Yasuhiro、Tamura Natsuko、Shiheido-Watanabe Yuka、Konishi Masanori、Ashikaga Takashi、Hirao Kenzo、Isobe Mitsuaki
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 5 Pages: 799-816

    • DOI

      10.1002/2211-5463.12416

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study2018

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 6 Pages: 777-782

    • DOI

      10.2169/internalmedicine.9578-17

    • NAID

      130006507416

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia2017

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
    • Journal Title

      BMC Cardiovascular Disorders

      Volume: 17 Issue: 1 Pages: 267-267

    • DOI

      10.1186/s12872-017-0703-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>Porphyromonas Gingivalis</i> Elevated High-Mobility Group Box 1 Levels After Myocardial Infarction in Mice2017

    • Author(s)
      Rungtiwa Srisuwantha、 Yuka Shiheido、 Norio Aoyama、 Hiroki Sato、 Keitetsu Kure、 Narongsak Laosrisin、 Yuichi Izumi、 Jun-ichi Suzuki
    • Journal Title

      International Heart Journal

      Volume: 58 Issue: 5 Pages: 762-768

    • DOI

      10.1536/ihj.16-500

    • NAID

      130006179119

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation2017

    • Author(s)
      Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
    • Journal Title

      Heart Vessels

      Volume: 32 Issue: 11 Pages: 1314-1319

    • DOI

      10.1007/s00380-017-1003-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations among tooth loss, systemic inflammation and antibody titers to periodontal pathogens in Japanese patients with cardiovascular disease2017

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Minabe Masato、 Izumi Yuichi、Isobe Mitsuaki
    • Journal Title

      Journal of Periodontal Research

      Volume: 53 Issue: 1 Pages: 117-122

    • DOI

      10.1111/jre.12494

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese workers with long leisure time have deteriorated periodontal condition: A cross-sectional study2017

    • Author(s)
      Aoyama Norio、Suzuki Jun-ichi、Sato Hiroki、Yoshida Asuka、Shiheido Yuka、Izumi Yuichi
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59 Issue: 2 Pages: 104-107

    • DOI

      10.1016/j.job.2017.01.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Apolipoprotein A-1 is a Candidate of Novel Biomarkers of Takayasu Arteritis.2019

    • Author(s)
      田村夏子、前嶋康浩、始平堂由佳、伊藤祐輔、平尾見三、磯部光章
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Critical role for dipeptidyl peptidase-4 activity in the pathogenesis of experimental autoimmune myocarditis.2018

    • Author(s)
      Yasuhiro Maejima, Yuka Shiheido-Watanabe, Natsuko Tamura, Yusuke Ito, Kenzo Hirao, Mitsuaki Isobe.
    • Organizer
      Heart Failure Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SGLT2 inhibitor directly protects oxidative stress-mediated cardiomyocyte injury by suppressing mitochondrial damage-mediated apoptosis.2018

    • Author(s)
      Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Yusuke Ito, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe.
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2020-03-30  

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