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Periodontal disease and the risk factors for atherosclerosis among subjects who received general medical check-ups

Research Project

Project/Area Number 17K17366
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Social dentistry
Research InstitutionNiigata University

Principal Investigator

YONEZAWA Daisuke  新潟大学, 医歯学系, 助教 (90711896)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords歯周炎 / 歯槽骨吸収 / 成人健診 / メタボリックシンドローム / 歯周病 / 就労世代 / 動脈硬化性疾患 / コホート研究
Outline of Final Research Achievements

To investigate whether the presence of periodontal disease is associated with future deterioration of the risk markers for atherosclerotic vascular disease. The subjects between 2004 and 2015 to receive general medical check-ups were enrolled and classified into two groups (mild/moderate and severe) according to their alveolar bone resorption (ABR) at baseline. The associations between changes in BMI, HbA1c, LDL-C, HDL-C, LDL-C/HDL-C ratio over a 5-year period and the severity of ABR were evaluated retrospectively. Subjects with moderate/severe ABR demonstrated significantly higher LDL-C/HDL-C ratio, HbA1c levels, and lower HDL-C levels, than those with mild ABR at baseline. LDL-C levels significantly deteriorated in subjects with moderate/severe ABR, and HDL-C deteriorated to a lesser extent in those with mild ABR over the 5-year period. Subjects with severe periodontitis may have a greater chance of developing atherosclerotic vascular disease.

Academic Significance and Societal Importance of the Research Achievements

就労世代からその後の高齢者に至るまでの歯科保健を向上させるためには,就労世代における歯科疾患のリスクに関する要因分析が重要であると考えた.歯周病が生活習慣病に関連することを明らかにし,さらに新たな歯科保健プログラムの構築を行うことにより,歯周病を予防し,わが国における医療費の削減,健康寿命の延伸に寄与することを目的とした.
その結果,歯槽骨吸収量は心血管イベントリスク関連の検査項目のうちメタボリックシンドローム関連の指標値と関連することが示された.また,歯槽骨吸収が中等度以上であると,メタボリックシンドローム関連の指標値の経年的悪化が顕著である可能性が示唆された.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 2018 2017

All Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Effects of Erythromycin on Osteoclasts and Bone Resorption via DEL-1 Induction in Mice2021

    • Author(s)
      Tamura Hikaru、Maekawa Tomoki、Domon Hisanori、Hiyoshi Takumi、Hirayama Satoru、Isono Toshihito、Sasagawa Karin、Yonezawa Daisuke、Takahashi Naoki、Oda Masataka、Maeda Takeyasu、Tabeta Koichi、Terao Yutaka
    • Journal Title

      Antibiotics

      Volume: 10 Issue: 3 Pages: 312-312

    • DOI

      10.3390/antibiotics10030312

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-12020

    • Author(s)
      Maekawa Tomoki、Tamura Hikaru、Domon Hisanori、Hiyoshi Takumi、Isono Toshihito、Yonezawa Daisuke、Hayashi Naoki、Takahashi Naoki、Tabeta Koichi、Maeda Takeyasu、Oda Masataka、Ziogas Athanasios、Alexaki Vasileia Ismini、Chavakis Triantafyllos、Terao Yutaka、Hajishengallis George
    • Journal Title

      JCI Insight

      Volume: 5 Issue: 15 Pages: 136706-136706

    • DOI

      10.1172/jci.insight.136706

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice2020

    • Author(s)
      Hiyoshi Takumi、Domon Hisanori、Maekawa Tomoki、Yonezawa Daisuke、Kunitomo Eiji、Tabeta Koichi、Terao Yutaka
    • Journal Title

      Archives of Oral Biology

      Volume: 112 Pages: 104679-104679

    • DOI

      10.1016/j.archoralbio.2020.104679

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antibacterial activity of hinokitiol against both antibiotic‐resistant and ‐susceptible pathogenic bacteria that predominate in the oral cavity and upper airways2019

    • Author(s)
      Domon Hisanori、Hiyoshi Takumi、Maekawa Tomoki、Yonezawa Daisuke、Tamura Hikaru、Kawabata Shigetada、Yanagihara Katsunori、Kimura Osamu、Kunitomo Eiji、Terao Yutaka
    • Journal Title

      Microbiology and Immunology

      Volume: 63 Issue: 6 Pages: 213-222

    • DOI

      10.1111/1348-0421.12688

    • NAID

      40021941640

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection2019

    • Author(s)
      Nagai Kosuke、Domon Hisanori、Maekawa Tomoki、Hiyoshi Takumi、Tamura Hikaru、Yonezawa Daisuke、Habuka Rie、Saitoh Akihiko、Terao Yutaka
    • Journal Title

      Vaccine

      Volume: 37 Issue: 1 Pages: 160-168

    • DOI

      10.1016/j.vaccine.2018.11.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis2019

    • Author(s)
      Tamura Hikaru、Maekawa Tomoki、Domon Hisanori、Hiyoshi Takumi、Yonezawa Daisuke、Nagai Kosuke、Ochiai Akihito、Taniguchi Masayuki、Tabeta Koichi、Maeda Takeyasu、Terao Yutaka
    • Journal Title

      Archives of Oral Biology

      Volume: 98 Pages: 132-139

    • DOI

      10.1016/j.archoralbio.2018.11.021

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin‐dependent neutrophil lysis2019

    • Author(s)
      Hiyoshi Takumi、Domon Hisanori、Maekawa Tomoki、Nagai Kosuke、Tamura Hikaru、Takahashi Naoki、Yonezawa Daisuke、Miyoshi Tomohiro、Yoshida Akihiro、Tabeta Koichi、Terao Yutaka
    • Journal Title

      Microbiology and Immunology

      Volume: 63 Issue: 3-4 Pages: 100-110

    • DOI

      10.1111/1348-0421.12672

    • NAID

      40021899825

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 20172019

    • Author(s)
      Nagai Kosuke、Kimura Osamu、Domon Hisanori、Maekawa Tomoki、Yonezawa Daisuke、Terao Yutaka
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 25 Issue: 3 Pages: 229-232

    • DOI

      10.1016/j.jiac.2018.08.018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mechanism of Macrolide-Induced Inhibition of Pneumolysin Release Involves Impairment of Autolysin Release in Macrolide-Resistant Streptococcus pneumoniae2018

    • Author(s)
      Domon Hisanori、Maekawa Tomoki、Yonezawa Daisuke、Nagai Kosuke、Oda Masataka、Yanagihara Katsunori、Terao Yutaka
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 62 Issue: 11

    • DOI

      10.1128/aac.00161-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia2018

    • Author(s)
      Domon Hisanori、Nagai Kosuke、Maekawa Tomoki、Oda Masataka、Yonezawa Daisuke、Takeda Wataru、Hiyoshi Takumi、Tamura Hikaru、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Front Immunol

      Volume: 印刷中 Pages: 732-732

    • DOI

      10.3389/fimmu.2018.00732

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 42018

    • Author(s)
      Nagai Kosuke、Domon Hisanori、Maekawa Tomoki、Oda Masataka、Hiyoshi Takumi、Tamura Hikaru、Yonezawa Daisuke、Arai Yoshiaki、Yokoji Mai、Tabeta Koichi、Habuka Rie、Saitoh Akihiko、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Cell Immunol

      Volume: 325 Pages: 14-22

    • DOI

      10.1016/j.cellimm.2018.01.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] マウス歯牙結紮歯周炎モデルにおけるヒノキチオールの骨吸収抑制作用の解析2020

    • Author(s)
      日吉 巧, 土門 久哲, 前川 知樹, 田村 光, 米澤 大輔, 國友 栄治, 寺尾 豊, 多部田 康一
    • Organizer
      第65回春季日本歯周病学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 好中球エラスターゼによる歯周炎重症化メカニズム解析と新規治療法への応用2020

    • Author(s)
      日吉 巧, 土門 久哲, 前川 知樹, 田村 光, 米澤 大輔, 多部田 康一, 寺尾 豊
    • Organizer
      令和2年度新潟歯学会第2回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フッ化物応用による歯のフッ素症の評価 -とくに6歳未満における局所応用の考え方-2020

    • Author(s)
      米澤大輔;筒井昭仁;八木稔
    • Organizer
      第69回日本口腔衛生学会・総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Alveolar bone resorption and the risk factors for atherosclerosis among subjects who received general medical check-ups in Japan.2020

    • Author(s)
      Daisuke, Y, Akihiro Y, Kazuhisa Y
    • Organizer
      International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Aggregatibacter actinomycetemcomitans Leukotoxin Induce Periodontal Tissue Destruction Via Neutrophil Elastase.2020

    • Author(s)
      Hiyoshi T, Domon H, Maekawa T, Tamura H, Yonezawa D, Terao Y, Tabeta K
    • Organizer
      The 98th General Session of the International Association for Dental Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Erythromycin suppresses inflammatory bone loss through reinduction of DEL-1.2020

    • Author(s)
      Tamura H, Maekawa T, Domon H, Hiyoshi T, Yonezawa D, Nagai K, Maeda T, Terao Y, Tabeata K
    • Organizer
      The 98th General Session of the International Association for Dental Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の検証2019

    • Author(s)
      田村 光, 前川 知樹, 土門 久哲, 日吉 巧, 米澤 大輔, 永井 康介, 前田 健康, 寺尾 豊, 多部田 康一
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] フッ化物洗口プログラムへの参加状況と成人期における歯のフッ素症の発現状況との関連2019

    • Author(s)
      米澤 大輔, 八木 稔, 福島 正義, 葭原 明弘
    • Organizer
      日本歯科衛生学会第14回学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 米由来ペプチドによる炎症制御機構の検索と歯周病治療への応用研究2019

    • Author(s)
      田村 光, 前川 知樹, 土門 久哲, 日吉 巧, 米澤 大輔, 前田 健康, 多部田 康一, 寺尾 豊
    • Organizer
      令和元年度新潟歯学会第 2 回例会
    • Related Report
      2019 Research-status Report
  • [Presentation] Preventive effect of preschool and school-based fluoride mouth rinsing program on dental caries in early adulthood.2019

    • Author(s)
      Yonezawa D, Yagi M, Yoshihara A
    • Organizer
      The International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of the food peptides on inflammatory bone loss.2018

    • Author(s)
      Yonezawa D, Maekawa T, Tamura T, Domon H, Nagai K, Hiyoshi T, Tabeta K, Maeda T
    • Organizer
      The 96th General Session of the International Association for Dental Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of the association between alveolar bone resorption and atherosclerosis risk2017

    • Author(s)
      Daisuke Yonezawa, Hiroki Koide, Ayano Aruga, Syunsuke Takahashi, Takeshi Tsutsumi, Shinpei Kumagai, Takako Nakajima, Kazuhisa Yamazaki
    • Organizer
      12th meeting of the Asian Pacific Society of Periodontology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Alveolar bone resorption and the risk factors for atherosclerosis among subjects who received general medical check-ups in Japan: follow-up study of the Nagano Health Promotion Project2017

    • Author(s)
      Daisuke Yonezawa, Hiroki Koide, Ayano Aruga, Syunsuke Takahashi, Takeshi Tsutsumi, Shinpei Kumagai, Kyoko Yamazaki, Takako Nakajima, Kazuhisa Yamazaki
    • Organizer
      65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2022-01-27  

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