| Project/Area Number |
17K17375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Takeuchi Kenji 九州大学, 歯学研究院, 共同研究員 (10712680)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 認知症 / 歯数 / 酸化ストレス / MRI / 歯周病 / アルツハイマー病 / 歯学 |
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| Outline of Final Research Achievements |
This study clarified oral-related risk factors contributing to the onset and progression of dementia in a community-dwelling adults aged 65 years or over in Hisayama town, adjusting for potential confounders. Salivary oxidative stress markers in Alzheimer's disease patients were significantly lower than those in healthy controls. In linear regression models, tooth loss was significantly positively associated with global brain atrophy, but not hippocampal atrophy, one of the morphological features of Alzheimer's disease.
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| Academic Significance and Societal Importance of the Research Achievements |
認知症の発症・進行に寄与する口腔関連リスク因子の解明をさらに発展させるため、唾液中の酸化ストレスマーカーを口腔関連の客観的指標として追加し、認知機能低下の客観的指標として核磁気共鳴映像法（MRI）検査に基づく脳萎縮度の判定を採用した点が本研究の学術的新規性と考える。研究成果の社会的意義として、口腔関連指標の中でも特に、歯の喪失は認知症の発症・進行に寄与する可能性が高く、高齢期に先駆けて幼年期・成人期から一貫して歯の喪失予防に努めることが認知症予防に重要であることが示唆された。
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