| Project/Area Number |
17K17431
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical nursing
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | 急性大動脈解離 / 心臓血管外科 / 保存的 / 自律神経活動 / 血圧変動 / 安静降圧療法 / 心拍変動 / 周術期看護 |
|---|
| Outline of Final Research Achievements |
In patients with type B acute aortic dissection requiring conservative therapy, the balance of autonomic nervous activity is presumably disturbed by the acute inflammatory response and pain, which may affect blood pressure control; however, the changes in autonomic nervous activity after acute aortic dissection have not been elucidated. Therefore, we aimed to clarify the changes in autonomic activity in the patients. Between September 2017 and March 2020, patients with type B acute aortic dissection who were hospitalized and treated with rest and antihypertensive therapy were enrolled in two centers. Analysis of heart rate variability and blood pressure variability allowed for noninvasive assessment of autonomic nervous system activity, and baroreceptor reflex sensitivity was also examined.
|
| Academic Significance and Societal Importance of the Research Achievements |
これまでに検証されていなかった急性疾患という特徴を有している急性大動脈解離における経時的および経日的な自律神経活動の変化を明らかにすることが出来た。血圧変動が、退院後の大動脈関連イベント（再入院、予定外手術など）に影響する可能性が示唆されていることから、これら自律神経活動の変化も関連している可能性が考えられる。自律神経活動の変化が大きいときの離床は血圧変動に影響をおよぼすかもしれない。
|
