Elucidation of the effects of cognitive rehabilitation for schizophrenia on neural activity in the brain

• Project/Area Number: 17K17556
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering; Applied health science
• Research Institution: Osaka Kawasaki Rehabilitation University (2020-2022); Hokkaido University (2017-2019)
• Principal Investigator: INOUE Takao 大阪河崎リハビリテーション大学, リハビリテーション学部, 講師 (40779427)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 認知機能 / 神経可塑性 / 事象関連電位 / 統合失調症 / 神経可塑桂 / リハビリテーション / 精神障害 / 認知機能改善療法 / 精神科リハビリテーション / 認知リハビリテーション

Outline of Final Research Achievements

From the results obtained, cognitive rehabilitation intervention by NEAR improves performance in behavioral tests such as neuropsychological tests, but ERP such as P300 during attention tasks and late positive components during memorization tasks, and time-frequency analysis It was clarified that the change in the power value of neural activity in each band caused by the effect did not change the neural activity of the brain at a level at which the effect could be grasped.

Academic Significance and Societal Importance of the Research Achievements

得られた結果より、NEARによる認知リハ介入では神経心理学検査などの行動学検査では成績が向上するが、注意課題時のP300や記銘課題時の後期陽性成分などのERP、また時間周波数解析による各帯域の神経活動のパワー値の変化では効果を把握できるレベルでは脳の神経活動には変化が生じないということが明らかになった。研究成果は国際学会で報告し、投稿した論文は現在査読中である。

Research Products

• [Journal Article] Late-life Depression and Rehabilitation. (2020)
  • Author(s): Masatoshi TAKEDA, Kenji ISHIKAWA, Takao INOUE ,et al
  • Journal Title: Cognition & Rehabilitation Volume: １ Pages: 112-116
  • NAID: 120007139599
  • Peer Reviewed
• [Journal Article] 認知機能障害に焦点をあてたリワーク (2020)
  • Author(s): 北川信樹，井上貴雄
  • Journal Title: 臨床精神薬理 Volume: 22
• [Journal Article] Effects of colour narrative in community-dwelling older adults:A mixed methods study. (2020)
  • Author(s): Risa Takashima, Takao Inoue* ,Yuko Yoshida ,et al
  • Journal Title: Scandinavian Journal of Occupational Therapy Volume: 5 Issue: 7 Pages: 1-13
  • DOI: 10.1080/11038128.2020.1849395
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 気分障害に焦点を当てたリワーク (2019)
  • Author(s): 北川信樹、井上貴雄
  • Journal Title: 臨床精神薬理 Volume: 22 Pages: 43-50
• [Journal Article] 精神科クリニックにおける認知リハビリテーションの実践 (2018)
  • Author(s): 井上貴雄
  • Journal Title: 北海道作業療法 Volume: 35 Pages: 17-24
  • NAID: 40021497244
• [Presentation] Relationship between cognitive impairment and the Purdue Pegboard test in schizophrenic patients (2022)
  • Author(s): Takao Inoue，Saki Takei，Narumi Sato，Takumi Tominaga
  • Organizer: 18th WFOT Congress
  • Int'l Joint Research
• [Presentation] 統合失調症に対する認知矯正療法が脳の神経活動に与える影響 (2019)
  • Author(s): 井上貴雄
  • Organizer: 日本統合失調症学会
• [Presentation] The effect of cognitive remediation therapy on the Event-Related Potential of schizophrenic patients (2018)
  • Author(s): Takao Inoue
  • Organizer: the XIII WAPR（World Association for Psychosocial Rehabilitation ） World Congress
  • Int'l Joint Research
• [Presentation] The effect of cognitive remediation therapy on schizophrenic patients on ERP (2017)
  • Author(s): Takao Inoue
  • Organizer: World psychiatric Association 17th World Congress in Berlin
  • Int'l Joint Research