| Project/Area Number |
17K17572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
General physiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 血液網膜関門 / トロンビン / プロテアーゼ活性型受容体 / PAR / 網膜静脈分枝閉塞症 / BRVO / PARs / PAR-1 / 網膜循環 / 網膜動脈 / 微小循環 / 網膜血管 / プロテアーゼアクティベイティドレセプター |
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| Outline of Final Research Achievements |
It was found that thrombin causes vasoconstriction when administered from the outside of the retinal vessel, but not when administered from the inside of the retinal vessel. This is supported by the previous report that the blood-retinal barrier does not allow passage of substances with a molecular weight above 1 kDa because thrombin has a large molecular weight of 33.6 kDa. As a result, it was considered that intravascular administration failed to act on smooth muscle and vasoconstriction could not occur. From these results, blood flow data of branch retinal vein occlusion (BRVO), which may leak from retinal vessels and act from outside the retinal vessels, is collected rather than the originally planned diabetic retinopathy. It was suggested that the blood flow was related to the change in retinal vein diameter, and the change in the diameter was related to the maximum best-corrected visual acuity.
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| Academic Significance and Societal Importance of the Research Achievements |
トロンビンは血液網膜関門を通過できず、血管内からは平滑筋に作用できないが、血液が血管より漏れ、血管外から作用しうる網膜静脈分枝閉塞症(BRVO)のような疾患に移おいては、網膜血管を収縮させ血流を悪くする可能性があるが、BRVOの血流データを収集したところ、網膜静脈血流は低下しており、その低下には血管径が細くなっていることが関与していることが分かったが、一方で、網膜静脈の血管径が小さい方が最高矯正視力が良いことわかった。このことから、BRVOのより良い治療を行うためには網膜静脈径の変化に伴う、網膜静脈組織の構造変化へアプローチすることが重要であることが示唆される。
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