Study of bone metabolic control mechanism due to fibroblasts and application to treatment of bone resorption disease.

• Project/Area Number: 17K17578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry; Orthopaedic surgery
• Research Institution: Hirosaki University
• Principal Investigator: Ito Ryohei 弘前大学, 医学研究科, 講師 (20638902)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 骨芽細胞 / 線維芽細胞 / 骨代謝 / 骨吸収 / 骨形成 / メカニカルストレス / 骨微小環境 / メカノセンサー / 細胞間相互作用 / 再生医学

Outline of Final Research Achievements

Ths research showed the fibroblasts under effect of the mechanical stress control bone metabolism of the co-cultured osteoblasts by changing a production of IGFBPs over time.The fibroblasts constituting bone microenvironment would control bone metabolism via IGFBPs.
The result indicats that unknown control mechanism by the bone microenvironment mainly composed of fibroblasts would be presented.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、線維芽細胞が作る骨微小環境が骨代謝制御に関与しており、その制御機能の重要な遺伝子がIGFBPであることをはじめて示した。
これは、骨粗鬆症をはじめとする骨吸収性疾患に対する新しい治療法に応用できる知見である。超高齢社会となり骨吸収性疾患の罹患率や影響が増大するなかで、社会的意義は大きいと考えられ、さらなる研究を進める必要がある。

Research Products

• [Journal Article] Chronological Changes in Gene Expression of Osteoblast Differentiation Factor and Insulin-Like Growth Factor-Binding Proteins Induced by Mechanical Stress in Osteoblast-Like Cells (2018)
  • Author(s): Ryohei Ito
  • Journal Title: Oral Science in Japan2018 Volume: - Pages: 5-8
  • Open Access / Int'l Joint Research