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Development of High-Accuracy Tumor Tracking Systems for Next-Generation Radi ation Therapy Technology

Research Project

Project/Area Number 17K17582
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Life / Health / Medical informatics
Research InstitutionSendai National College of Technology

Principal Investigator

Zhang Xiaoyong  仙台高等専門学校, 総合工学科, 助教 (90722752)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords画像誘導放射線治療 / マーカレス追尾照射 / Radiation therapy / Tumor tracking / Hidden Markov model / IGRT / Radiographic imaging / Radiation Therapy / Markerless Tracking / Radiographic Imaging
Outline of Final Research Achievements

This research focused on developing a radiographic image tracking system to track the tumor motion in real-time for adaptive tumor following radiation therapy. In this research projects, we have developed a robust tracking system that is capable of tracking the tracking the tumor’s position and its boundary in radiographic images. The experimental results performed on the phantom and clinical data demonstrated that the effectiveness of the tracking systems for clinical application.

Academic Significance and Societal Importance of the Research Achievements

放射線治療において,治療効果を高めつつ副作用を避けるためには,病巣周辺の健康な組織への照射を極力避け,腫瘍のみへの正確な照射が要求される。提案手法を用いて,実際に放射線治療を行っている際の腫瘍位置や形状などを自動的にリアルタイムに把握することは,正常組織障害の低減の同時に、放射線治療の精度を向上できると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (19 results) (of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Hidden Markov Model-based Extraction of Target Objects in X-ray Image Sequence for Lung Radiation Therapy2020

    • Author(s)
      新藤 雅大, 市地 慶, 本間 経康, 張 曉勇, 奥田 隼梧, 杉田 典大, 八巻 俊輔, 髙井 良尋, 吉澤 誠
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 140 Issue: 1 Pages: 49-60

    • DOI

      10.1541/ieejeiss.140.49

    • NAID

      130007779196

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2020-01-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A key-point based real-time tracking of lung tumor in X-ray image sequence by using difference of Gaussians filtering and optical flow2018

    • Author(s)
      Kei Ichiji, Yusuke Yoshida, Noriyasu Homma, Xiaoyong Zhang, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
    • Journal Title

      Phys Med Biol

      Volume: 63 Issue: 18 Pages: 1-16

    • DOI

      10.1088/1361-6560/aada71

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Deep Learning-based Computer-aided Diagnosis System for Mammographic Lesion Detection2018

    • Author(s)
      SUZUKI Shintaro、ZHANG Xiaoyong、HOMMA Noriyasu、ICHIJI Kei、TAKANE Yumi、YANAGAKI Satoru、KAWASUMI Yusuke、ISHIBASHI Tadashi、YOSHIZAWA Makoto
    • Journal Title

      Transactions of the Society of Instrument and Control Engineers

      Volume: 54 Issue: 8 Pages: 659-669

    • DOI

      10.9746/sicetr.54.659

    • NAID

      130007437725

    • ISSN
      0453-4654, 1883-8189
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dosimetric evaluation of MLC-based dynamic tumor tracking radiotherapy using digital phantom: Desired setup margin for tracking radiotherapy2018

    • Author(s)
      Kadoya Noriyuki、Ichiji Kei、Uchida Tomoya、Nakajima Yujiro、Ikeda Ryutaro、Uozumi Yosuke、Zhang Xiaoyong、Bukovsky Ivo、Yamamoto Takaya、Takeda Ken、Takai Yoshihiro、Jingu Keiichi、Homma Noriyasu
    • Journal Title

      Medical Dosimetry

      Volume: 43 Issue: 1 Pages: 74-81

    • DOI

      10.1016/j.meddos.2017.08.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 最大リャプノフ指数推定に基づく呼吸性移動時系列の予測可能性の検討2017

    • Author(s)
      市地慶,本間経康,張暁勇,武田賢,高井良尋,杉田典大,吉澤誠
    • Journal Title

      東北医学雑誌

      Volume: 129 Pages: 47-47

    • Related Report
      2017 Research-status Report
  • [Presentation] A Comparison Study of Deep Learning Techniques for Mass Detection in Mammograms2019

    • Author(s)
      K. Noro, Xiaoyong. Zhang, H. Takano, K. Ichiji, N. Homma
    • Organizer
      2019 AAPM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Risk Analysis of Bilateral Mammographic Density Differences for Breast Cancer: A Case-Control Study2019

    • Author(s)
      Jiaqi Chen, Xiaoyong Zhang, Tadashi Ishibashi, Yumi Takane, Satoru Yanagaki, Daisuke Shibuya, Kei Ichiji, Makoto Osanai, Noriyasu Homma
    • Organizer
      第27回日本乳癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Deep Learning for Drowning Diagnosis using Post-mortem Lung CT Images2019

    • Author(s)
      本間経康, 佐藤亮太, 張暁勇, 今野拓也, Amber Qureshi, 市地慶, 臼井彰人, 川住祐介, 舟山眞人
    • Organizer
      SICE システム・情報部門 知能工学部会 第47回知能システムシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 4次元CT補間に基づく隠れマルコフモデルを用いたX線動画像中の腫瘍像描出能 向上2019

    • Author(s)
      奥田隼梧,市地慶,本間経康,張曉勇, 吉澤誠
    • Organizer
      計測自動制御学会東北支部 55 周年記念学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Classification of Masses in Mammogram: A Comparison Study of State-of-the-Art Deep Learning Technologies2018

    • Author(s)
      H. TAKANO, X. ZHANG, N. HOMMA, M. YOSHIZAWA
    • Organizer
      The 60th AAPM annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳房X線画像における画像診断が難しい腫瘤に対する 深層学習を用いた良悪性鑑別の試み2018

    • Author(s)
      野呂恭平, 張暁勇, 高野寛己, 市地慶, 柳垣聡, 高根侑美, 石橋忠司, 本間経康
    • Organizer
      第 14回コンピューテショナル・イリジェス研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 乳房X線画像における良悪性鑑別が難しい腫瘤に対する深層学習の性能評価2018

    • Author(s)
      野呂恭平, 張暁勇, 高野寛己, 市地慶, 柳垣聡, 高根侑美, 石橋忠司, 本間経康
    • Organizer
      日本放射線技術学会第46回秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Probabilistic Decomposition of X-Ray Image Sequence to Extract Obscure Target Objects for Monitoring Intrafractional Organ Motion2018

    • Author(s)
      M Shindo, K Ichiji, N Homma, X Zhang, Y Takai, M Yoshizawa
    • Organizer
      The 60th AAPM annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] マーカレス腫瘍追跡のための隠れマルコフモデルを用いたX線動画像から の物体輝度抽出2018

    • Author(s)
      新藤雅大,市地慶,本間経康,張曉勇, 杉田典大,八巻俊輔,髙井良尋,吉澤誠
    • Organizer
      第28回インテリジェント・システム・シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] Tumor tracking by integrating multiple sensing results for radiation therapy2018

    • Author(s)
      W. Wu, K. Ichiji, X. Zhang, I. Bukovsky, M. Osanai, Y. Takai, N. Homma
    • Organizer
      計測自動制御学会システム・情報部門 学術講演会(SSI2018)
    • Related Report
      2018 Research-status Report
  • [Presentation] 呼吸性移動対策のための肺腫瘍位置の時系列成分分離に基づく予測2018

    • Author(s)
      佐藤雄介, 市地慶, 新藤雅大, 張暁勇, 角谷倫之,小山内実, 高井良尋, 本間経康
    • Organizer
      日本放射線技術学会第46回秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Computer-Aided Diagnosis of Micro-Calcication Clusters in Mammograms Using an Adaptive Gaussian Mixture Model2018

    • Author(s)
      Zhang ZHANG, Xiaoyong ZHANG, Kei ICHIJI, Makoto OSANAI, Noriyasu HOMMA
    • Organizer
      計測自動制御学会システム・情報部門 学術講演会(SSI2018)
    • Related Report
      2018 Research-status Report
  • [Presentation] Classification of Mammographic Masses by Deep Learning2017

    • Author(s)
      Xiaoyong Zhang, Takuya Sasaki, Shintaro Suzuki, Yumi Takane, Yusuke Kawasumi, Tadashi Ishibashi, Noriyasu Homma, Makoto Yoshizawa
    • Organizer
      SICE Annual Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Deep Convolutional Neural Networkの転移学習による乳房X線画像上の腫瘤検出2017

    • Author(s)
      鈴木真太郎, 張暁勇, 本間経康, 吉澤誠
    • Organizer
      計測自動制御学会東北支部第307回研究集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳がん病変検出のための深層学習を用いた計算機支援画像診断システム2017

    • Author(s)
      鈴木真太郎, 張曉勇、本間経康, 市地慶, 魚住洋佑, 高根侑美, 柳垣聡, 川住祐介, 石橋忠司, 吉澤誠
    • Organizer
      第11回コンピューテーショナル・インテリジェンス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 深層学習による乳房X線画像上の腫瘤鑑別2017

    • Author(s)
      鈴木真太郎, 張曉勇, 佐々木拓也, 本間経康, 市地慶, 魚住洋佑, 高根侑美, 柳垣聡, 川住祐介, 石橋忠司, 吉澤誠
    • Organizer
      第11回コンピューテーショナル・インテリジェンス研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Classification of Benign and Malignant Masses in Mammogram by Using Deep Convolutional Neural Network2017

    • Author(s)
      高野寛己,張曉勇,本間経康,吉澤誠
    • Organizer
      平成29年度電気関係学会東北支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 乳がん病変検出のための深層学習を用いた計算機支援画像診断システム2017

    • Author(s)
      鈴木真太郎,張曉勇,高根侑美,川住祐介,石橋忠司,本間経康,吉澤誠
    • Organizer
      計測自動制御学会 システム・情報部門学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] データ拡張を用いたDCNNによる乳房X線画像上の腫瘤鑑別性能向上2017

    • Author(s)
      高野寛己,張曉勇,本間経康,吉澤誠
    • Organizer
      計測自動制御学会 システム・情報部門学術講演会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] Image processing device, image processing method, and non-transitory computer-readable recording medium having stored therein image processing program2017

    • Inventor(s)
      本間経康、酒井正夫、市地慶、渋澤直樹、張暁勇、その他
    • Industrial Property Rights Holder
      東北大学、弘前大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2021-02-19  

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