| Project/Area Number |
17K17612
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
Cell biology
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| Research Institution | Akita University |
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Principal Investigator |
Itoh Go 秋田大学, 医学系研究科, 助教 (60607563)
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| Research Collaborator |
Tanaka Masamitsu
Goto Akiteru
Yashiro Masakazu
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌関連線維芽細胞 / 癌微小環境 / 癌浸潤モード / 癌ジオメトリー / 浸潤 / 癌関連線維芽細胞（CAF） / 癌浸潤 / アポトーシス / 細胞分裂 / 癌 / がん微小環境 / 細胞間相互作用 |
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| Outline of Final Research Achievements |
There are different modes of invasion in the process of cancer spread. One is expansive invasion, in which a group of cancer cells gradually expands along with cancer cell proliferation. The other is a more extensive invasion promoted by interactions with stromal cells, including cancer associated fibroblasts (CAF). In the present study, it was shown that CAF induces a certain number of apoptosis in gastric cancer cells, which prevents the cancer-expansive invasion, and instead promotes CAF-led widespread invasion.
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| Academic Significance and Societal Importance of the Research Achievements |
圧排性増殖型の浸潤癌は癌患部の切除によって根治可能である。一方、播種型浸潤の癌における予後は良くない。これらの浸潤型の選択メカニズムは不明であった。本研究では、世界に先駆けてこのメカニズムに注目し、その成果を論文報告した。今後、播種性浸潤の抑制に繋がる研究を進め、癌治療へ繋げることを目指している。
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