| Project/Area Number |
17K17631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
Biological pharmacy
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 尿路感染症 / バイオフィルム / 薬剤耐性 / 病原性 / 発現制御 / 環境応答 / 運動性 / 細菌 / 抗生物質 / 環境 / シグナル伝達 |
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| Outline of Final Research Achievements |
Uropathogenic E. coli is a major pathogen that causes urinary tract infections, and it exhibits pathogenicity only in the urinary tract but not enteric site and natural environment. In this study, we revealed the mechanism how virulence of Uropathogenic E. coli is induced under iron-limited conditions in urinary tract infection sites. In addition, we also found a novel virulence factor, TolB and also investigated its functions.
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| Academic Significance and Societal Importance of the Research Achievements |
尿路病原性大腸菌による感染症治療のために、各種抗菌薬が使用されているが、近年これらの抗菌薬に対する耐性菌（薬剤耐性菌）が増加傾向にあり、本感染症に対する予防法や治療法の発展が期待されている。本研究成果は、尿路病原性大腸菌感染症の増悪リスク予測や予防法、新規治療法の創成といった応用研究へ橋渡しを行うものである。
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