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Identification of gene mutation profiles related to responses to radiation therapy for oral cancer

Research Project

Project/Area Number 17K17632
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Pathobiological dentistry/Dental radiology
Research InstitutionUniversity of Toyama (2019)
Gunma University (2017-2018)

Principal Investigator

Tatsuji Mizukami  富山大学, 学術研究部医学系, 講師 (20746565)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords遺伝子変異 / 放射線感受性 / 口腔癌 / 放射線治療 / DNAシークエンス / 放射線治療感受性 / がん関連遺伝子 / 遺伝子異常 / 口腔がん / 放射線腫瘍学 / 歯科放射線学 / ゲノム医科学
Outline of Final Research Achievements

The purpose is to analyse the genetic relations with the preoperative radiation therapy for oral cancer.
The amount of extracted DNA varied depending on the lesion site, that obtained from gingival cancer was small. We used a next-generation sequencer and performed target-capture sequencing of the extraced DNA and analyzed mutational status in 50 kown cancer-related genes.
As a result, We identidfied that the number of gene mutationare greatly different in every sample. We are going to improve the DNA sampling method and analyze more sumples.

Academic Significance and Societal Importance of the Research Achievements

術後放射線治療を行った口腔癌の手術検体を用いて治療成績と関連する遺伝子の解析を試みた。
口腔癌の手術検体からDNAを抽出し、次世代シークエンサーを用いて50種類のがん関連遺伝子のホットスポットについて変異の解析を行った。
DNA抽出の段階で歯肉由来の検体ではDNAの回収が困難であることが判明した。遺伝子解析の結果、検体ごとで変異総数の差異が大きなことが判明した。臨床情報と関連づけるためにはさらに追加実験が必要と考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019

All Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (1 results)

  • [Journal Article] Moderately hypofractionated carbon ion radiotherapy for prostate cancer; a prospective observational study “GUNMA0702”2020

    • Author(s)
      Kawamura Hidemasa、Group for Genitourinary Tumors at Gunma University Heavy Ion Medical Center、Kubo Nobuteru、Sato Hiro、Mizukami Tatsuji、Katoh Hiroyuki、Ishikawa Hitoshi、Ohno Tatsuya、Matsui Hiroshi、Ito Kazuto、Suzuki Kazuhiro、Nakano Takashi
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12885-020-6570-8

    • NAID

      120007127660

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose assessment for patients with stage I non-small cell lung cancer receiving passive scattering carbon-ion radiotherapy using daily computed tomographic images: A prospective study2020

    • Author(s)
      Li Yang、Kubota Yoshiki、Kubo Nobuteru、Mizukami Tatsuji、Sakai Makoto、Kawamura Hidemasa、Irie Daisuke、Okano Naoko、Tsuda Kazuhisa、Matsumura Akihiko、Saitoh Jun-ichi、Nakano Takashi、Ohno Tatsuya
    • Journal Title

      Radiotherapy and Oncology

      Volume: 144 Pages: 224-230

    • DOI

      10.1016/j.radonc.2020.01.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypofractionated carbon-ion radiotherapy for stage I peripheral nonsmall cell lung cancer (GUNMA0701): Prospective phase II study.2019

    • Author(s)
      Saitoh JI, Shirai K, Mizukami T, Abe T, Ebara T, Ohno T, Minato K, Saito R, Yamada M, Nakano T. Hypofractionated carbon-ion radiotherapy for stage I peripheral nonsmall cell lung cancer (GUNMA0701): Prospective phase II study. Cancer Med. 2019;8(15):6644-6650.
    • Journal Title

      Cancer Med.

      Volume: 8 Issue: 15 Pages: 6644-6650

    • DOI

      10.1002/cam4.2561

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma2019

    • Author(s)
      Kubo Nobuteru、Kubota Yoshiki、Kawamura Hidemasa、Oike Takahiro、Sakai Makoto、Kumazawa Takuya、Miyasaka Yuhei、Okazaki Shohei、Kobayashi Daijiro、Sato Hiro、Mizukami Tatsuji、Musha Atsushi、Shirai Katsuyuki、Saitoh Jun-ichi、Yokoo Satoshi、Chikamatsu Kazuaki、Ohno Tatsuya、Nakano Takashi
    • Journal Title

      Radiotherapy and Oncology

      Volume: 141 Pages: 72-77

    • DOI

      10.1016/j.radonc.2019.07.022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Carbon-ion Radiotherapy for Isolated Lymph Node Metastasis After Surgery or Radiotherapy for Lung Cancer2019

    • Author(s)
      Shirai Katsuyuki、Kubota Yoshiki、Ohno Tatsuya、Saitoh Jun-ichi、Abe Takanori、Mizukami Tatsuji、Mori Yasumasa、Kawamura Hidemasa、Akahane Keiko、Nakano Takashi
    • Journal Title

      Frontiers in Oncology

      Volume: 9 Pages: 931-931

    • DOI

      10.3389/fonc.2019.00731

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypofractionated Intensity-modulated Radiotherapy for Intermediate- and High-risk Prostate Cancer: A Retrospective Study2019

    • Author(s)
      KUBO NOBUTERU、KAWAMURA HIDEMASA、OIKE TAKAHIRO、SATO HIRO、IWANAGA MOTOTARO、MIZUKAMI TATSUJI、ADACHI AKIKO、MATSUI HIROSHI、ITO KAZUTO、SUZUKI KAZUHIRO、NAKANO TAKASHI
    • Journal Title

      In Vivo

      Volume: 33 Issue: 4 Pages: 1235-1241

    • DOI

      10.21873/invivo.11595

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective Study of Isolated Recurrent Tumor Re-irradiation With Carbon-Ion Beams.2019

    • Author(s)
      Shirai K, Ohno T, Saitoh JI, Okamoto M, Katoh H, Murata K, Kawamura H, Musha A, Abe T, Mizukami T, Akahane K, Nakano T.
    • Journal Title

      Front Oncol.

      Volume: 9 Pages: 181-181

    • DOI

      10.3389/fonc.2019.00181

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term outcome of hypofractionated intensity-modulated radiotherapy using TomoTherapy for localized prostate cancer: A retrospective study2019

    • Author(s)
      Takakusagi Yosuke、Kawamura Hidemasa、Okamoto Masahiko、Kaminuma Takuya、Kubo Nobuteru、Mizukami Tatsuji、Sato Hiro、Onishi Masahiro、Ohtake Nobuaki、Sekihara Tetsuo、Nakano Takashi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 2 Pages: e0211370-e0211370

    • DOI

      10.1371/journal.pone.0211370

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 限局声門癌に対する加速放射線治療2019

    • Author(s)
      水上達治、山岸健太郎、野村邦紀、阿部秀晴、石田正幸、將積日出夫、齋藤淳一
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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