| Project/Area Number |
17K17644
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
Legal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GONOI Wataru 東京大学, 医学部附属病院, 助教 (60631174)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 死亡時画像診断 / 死後画像診断 / Postmortem Imaging / Forensic Radiology / 死後CT / Autopsy imaging / Postmortem CT / Virtopsy / Autopsy Imaging / 解剖 / CT / Postmortem imaging / Radiology / Computed tomography / Forensic radiology |
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| Outline of Final Research Achievements |
I conducted postmortem computed tomography (PMCT) in patients following non-traumatic in-hospital death. PMCT findings were compared to the clinical course, antemortem computed tomography (AMCT)findings, and autopsy findings. I assessed the following items: (1) PMCT of the lungs; (2) PMCT of the pulmonary vessels; (3) PMCT of ascites; (4) PMCT of the liver; (5) PMCT of the children up to 3 years of age. As a result, I found the following findings: (1) Some pulmonary PMCT findings increased with time elapsed since death, and specific findings were useful to diagnose pneumonia and pulmonary edema; (2) Diameters of pulmonary vessels decreased with time since death; (3) Elevation in CT value of ascites was observed due to administration of contrast-medium shortly before death; (4) CT value of the liver significantly decreased on PMCT compared to that of AMCT; (5) PMCT could improve diagnosis of causes of death over clinical diagnosis alone in fetuses and children.
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| Academic Significance and Societal Importance of the Research Achievements |
死亡時画像診断は、重要な死因推定手段であるが、未だに多くの臓器や疾患で正しい解釈方法が明らかでない。肺や肺血管は死因に関与することが多いにも拘らず、これまで死後CT所見の報告が乏しく、判断材料に欠けていた。今回の研究では、正常な肺・肺動静脈の死後CT所見から始まり、頻度の高い肺炎や肺水腫の死後CT所見を明らかにした。本研究結果は、死後CTによる肺病変の診断を大きく前進させるものである。また、今回は腹水や肝臓についても新たな知見を得た。新生児や乳幼児においては、死後CTの施行が死因診断を改善することも明らかにした。死因推定の精度向上は、医療の発展、犯罪見逃し減少、社会の安寧に役立つ。
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