| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In Drosophila, the mushroom body (MB) has been studied for its essential role in olfactory associative memory. It has been known that Kenyon cells (KCs), the 3rd-ordered intrinsic neurons, are anatomically subdivided into distinct 7 subtypes and each type seems to play different functional role during the memory. Their output sites, called γ(m and d), α'/β'(ap and s), and α/β(p, s, and c) lobes, are compartmentalized into 15 sub-regions by their synaptic partners, MBONs and DANs. Moreover, post-synaptic plasticity has been shown in several types of MBONs by 2-photon calcium imaging with single cell level resolution.
However, it is not clear whether such plasticity is also detectable in the pre-synaptic sites of MB, the axonal lobes of KCs. To address this question, we first aimed to describe dynamics of the innate odor responses of the 7 KC subtypes using cell type specific split-gal4 drivers, combining with the lexA-based compartment labeling in their output regions.
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