Project/Area Number |
17K17688
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Laboratory animal science
Obstetrics and gynecology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Suzuki Hitomi 東京医科歯科大学, 統合研究機構, 助教 (60644094)
|
Project Period (FY) |
2017-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 卵母細胞 / 卵胞成熟 / 女性不妊 / 原始卵胞 / マウス / 発現制御 / 実験動物 / 不妊治療 |
Outline of Final Research Achievements |
Each oocyte is maintained in a follicle with some somatic cells, Granulosa cells, in mammalian ovary. Most immature “primordial follicles” are dormant and stored during a long life until receiving activation signals and entering to folliculogenesis pathway for maturation. We revealed that Protein arginine methyltransferase 5 (Prmt5) play an important role in mouse oogenesis for maintain the genome integrity of dormant oocytes. Prmt5 cKO oocytes cannot maintain the dormancy and showed abnormal gene expression profile, leading the mouse to premature ovarian insufficiency.
|
Academic Significance and Societal Importance of the Research Achievements |
体内で長期間休眠状態にある卵母細胞がどのように管理され、品質を保っているか、そのメカニズムの一端を、本研究で示すことができた。この結果は将来、再生医療や不妊治療法の開発・改善に寄与することができると考えている
|