Preventive effects of triterpenes cancer cachexia-induced muscle atrophy
| Project/Area Number |
17K17746
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
Food science
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| Research Institution | Toyama College (2018-2019)
University of Toyama (2017) |
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Principal Investigator |
Fujita Kyosuke 富山短期大学, その他部局等, 講師 (70707538)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 筋萎縮 / トリテルペン / オレアノール酸 / がん悪液質 / 筋委縮 / エゴマ葉 / C2C12細胞 |
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| Outline of Final Research Achievements |
Triterpenes such as oleanolic acid are contained in foods of plant origin. In this study, we investigated the effects of triterpenes on cancer cachexia-induced muscle atrophy in vitro and in vivo. We show that oleanoic acid had no effect on in vitro atrophy model. cancer cachexia-induced muscle atrophy was suppressed in the mice fed oleanolic acid-containing diet or perilla leaf-containing diet.
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| Academic Significance and Societal Importance of the Research Achievements |
がん悪液質とは、多くのがん患者の生活の質を低下させる原因となる、筋肉の衰え（筋萎縮）・体重減少・食欲不振などの症状である。現在、がん悪液質に対する効果的な治療法が確立されておらず、新規の治療法を見出す必要性がある。本研究成果は、エゴマ葉などのトリテルペンを多く含む食品の摂取が、がん悪液質性の筋萎縮に対する新規の食事治療法の一つになりうることを示すことができた。
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Report
(4 results)
Research Products
(10 results)
