| Project/Area Number |
17K17758
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
Tumor biology
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| Research Institution | Kanazawa University |
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Principal Investigator |
KASAHARA Atsuko 金沢大学, がん進展制御研究所, 助教 (00447244)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミトコンドリア動態 / カルシウム制御 / カルシウム調節 |
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| Outline of Final Research Achievements |
Glioblastoma (GBM) is a very aggressive and destructive brain tumour. Numerous studies have identified a tumour cell population in GBM that can initiate glioma development, as glioma stem-like cells. We observed the specific mitochondrial shape, and intracellular localisation in glioma stem-like cells, that regulates sialylated glycan expressions at the plasma membrane, which directly influences the physiological contact, and killing efficiency of cytotoxic T lymphocyte to the glioma stem-like cells.
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| Academic Significance and Societal Importance of the Research Achievements |
これまでがん細胞では、エネルギー代謝制御におけるミトコンドリアの役割が注目・研究されてきた。本研究では、ミトコンドリアの形態や細胞内局在が、がん細胞の悪性形質を制御し、がん免疫療法の効率に関わることを初めて明らかにした。本研究の成果は、悪性がん細胞特異的なミトコンドリア動態が、治療標的となりうる可能性を示唆し、新規のがん治療研究への布石となったと考えている。
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