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One-dimensional molecular immobilization method using molecular-orientation on the polymer nanofibers surface

Research Project

Project/Area Number 17K17765
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biofunction/Bioprocess
Polymer/Textile materials
Research InstitutionUniversity of Fukui

Principal Investigator

Sakamoto Hiroaki  福井大学, 学術研究院工学系部門, 准教授 (70552454)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsナノ繊維 / 分子配向 / 高機能繊維 / エレクトロスピニング法 / 表面修飾 / 分子修飾 / 機能性繊維
Outline of Final Research Achievements

It is well-known that polymer materials are proceeded to nanofibers, not only they become thinner, but also the molecular orientation of the fibers is enhanced. Previously, we had observed the structure of the nanofiber surface by atomic force microscopy (AFM), and found that 20 nm molecular domains were aligned along the long axis of the fiber. In addition, we found that the adsorption properties of biomolecules were enhanced with the change in the molecular structure of the fiber surface. In this study, we have verified that molecules are adsorbed linearly in the direction of the fiber's long axis and established a one-dimensional molecular arrangement technique for application.

Academic Significance and Societal Importance of the Research Achievements

本研究で提案する「生体分子を材料表面へ一次元的に配置させる技術」は、異なる酵素による連続的なカスケード反応の解析ツール、特定の方向にのみ機能発現する材料(異方性材料)など機能性材料開発のための新たな手法として寄与することが期待される。本提案は、医療診断、創薬分野、および材料分野におけるあらたな材料開発の可能性を広げる基盤技術につながると考えられる。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (26 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Electrochemical characteristics of a gold nanoparticle-modified controlled enzyme?electrode contact junction electrode2021

    • Author(s)
      Mori Saki、Kitta Yohei、Sakamoto Hiroaki、Takamura Eiichiro、Suye Shin-ichiro
    • Journal Title

      Biotechnology Letters

      Volume: 43 Issue: 5 Pages: 1037-1042

    • DOI

      10.1007/s10529-021-03092-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of one-dimensional arrays of nanoparticles using segmented polyurethane nanofiber prepared by electrospinning2020

    • Author(s)
      T. Meboso, M. Horie, H. Sakamoto, E. Takamura, S. Suye
    • Journal Title

      Nanotechnology

      Volume: 31 Issue: 45 Pages: 455606-455606

    • DOI

      10.1088/1361-6528/ababca

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biocathode design with highly‐oriented immobilization of multi‐copper oxidase from Pyrobaculum aerophilum onto a single‐walled carbon nanotube surface via a carbon nanotube‐binding peptide2020

    • Author(s)
      Sakamoto Hiroaki、Futamura Rie、Tonooka Aina、Takamura Eiichiro、Satomura Takenori、Suye Shin‐ichiro
    • Journal Title

      Biotechnology Progress

      Volume: 37 Issue: 1 Pages: 1-6

    • DOI

      10.1002/btpr.3087

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanofiber-guided orientation of electrospun carbon nanotubes and fabrication of aligned CNT electrodes for biodevice applications2020

    • Author(s)
      H. Sakamoto, I. Fujiwara, E. Takamura, S. Suye
    • Journal Title

      Mater. Chem. Phys.

      Volume: 245 Pages: 122745-122745

    • DOI

      10.1016/j.matchemphys.2020.122745

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of electrothermal heat on driving of polymer nanofibers as an actuator2019

    • Author(s)
      Y. Sunahase, S. Matsui, S. Amaya, H. Sakamoto, S. Suye
    • Journal Title

      Sensor Actuat. A-Phys

      Volume: 295 Pages: 231-236

    • DOI

      10.1016/j.sna.2019.04.023

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Biofuel Cell Using a Complex of Highly Oriented Immobilized His-Tagged Enzyme and Carbon Nanotube Surface Through a Pyrene Derivative2019

    • Author(s)
      H. Sakamoto, A. Koto, E. Takamura, H. Asakawa, T. Fukuma, T. Satomura S. Suye
    • Journal Title

      J. Nanosci. Nanotechnol.

      Volume: 19 Issue: 6 Pages: 3551-3557

    • DOI

      10.1166/jnn.2019.16121

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 太さの異なるナノファイバーへのタンパク質吸着特性2019

    • Author(s)
      坂元博昭, 目細太一, 末信一朗
    • Journal Title

      電気学会論文誌E(センサ・マイクロマシン部門誌)

      Volume: 139

    • NAID

      130007657517

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A l-proline/O2 biofuel cell using l-proline dehydrogenase (LPDH) from Aeropyrum pernix2018

    • Author(s)
      A.Tonooka, T. Komatus, S. Tanaka, H. Sakamoto, T. Satomura, S. Suye
    • Journal Title

      Mol. Biol. Rep.

      Volume: 45 Issue: 6 Pages: 1821-1825

    • DOI

      10.1007/s11033-018-4328-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a high-sensitive electrochemical detector with micro-stirrer driven by surface acoustic waves2018

    • Author(s)
      Hiroaki Sakamoto, Hiroki Kitanishi, Satoshi Amaya, Tsunemasa Saiki, Yuichi Utsumi, and Shin-ichiro Suy
    • Journal Title

      Sensor and actuator B

      Volume: 260 Pages: 705-709

    • DOI

      10.1016/j.snb.2017.12.196

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication and Characterization of Fe/Polyurethane Nanofiber Actuator Prepared by Electrospinning2017

    • Author(s)
      H. Sakamoto, S. Amaya, Y. Sunahase and S. Suye
    • Journal Title

      Journal of Fiber Science and Technology

      Volume: 73 Issue: 6 Pages: 135-138

    • DOI

      10.2115/fiberst.2017-0019

    • NAID

      130005697137

    • ISSN
      2189-7654
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of protein adsorption on stretched polyurethane nanofibers prepared by electrospinning2017

    • Author(s)
      Morita Yuko、Sakamoto Hiroaki、Suye Shin-ichiro
    • Journal Title

      RSC Advances

      Volume: 7 Issue: 89 Pages: 56484-56488

    • DOI

      10.1039/c7ra11942a

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] ナノファイバーを用いたカーボンナノチューブ配向バイオカソードの構築2020

    • Author(s)
      二村梨絵, 坂元博昭, 髙村映一郎, 里村武範, 末信一朗
    • Organizer
      電気化学会第87回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ナノファイバーをガイドとしたカーボンナノチューブ配向電極の開発とそのバイオデバイスへの応用2019

    • Author(s)
      坂元博昭、藤原郁也, 髙村映一郎, 末信一朗
    • Organizer
      2019年度繊維学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 延伸ポリウレタンナノファイバーの分子配向を利用した白金ナノ粒子修飾繊維の開発2019

    • Author(s)
      目細太一, 坂元博昭, 末信一朗
    • Organizer
      2019年度繊維学会年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 白金ナノ粒子の表面分布を制御した活性酸素種分解ポリウレタン繊維の開発2019

    • Author(s)
      目細太一, 髙村映一郎, 坂元博昭, 末信一朗
    • Organizer
      第36回「センサ・マイクロマシンと応用システム」シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 電熱駆動型ナノファイバーアクチュエータの創成と駆動メカニズムの解明2018

    • Author(s)
      砂長谷祐樹, 天谷 諭, 坂元 博昭, 末 信一朗
    • Organizer
      平成30年度繊維学会秋季研究発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 延伸ナノ繊維表面に発現する直線状セグメントを利用した一次元分子修飾2018

    • Author(s)
      坂元 博昭, 森田 祐子, 目細 太一, 末 信一朗
    • Organizer
      平成30年度繊維学会秋季研究発表会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高性能バイオデバイスを目指したカーボンナノチューブ配向電極の開発2018

    • Author(s)
      藤原 郁也, 大池 智明, 松崎 祥平, 坂元 博昭, 末 信一朗
    • Organizer
      第70回生物工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高分子ナノファイバーを素子として用いたアクチュエータの電気刺激応答2018

    • Author(s)
      砂長谷祐樹, 三井 翔太, 天谷 諭, 坂元 博昭, 末 信一朗
    • Organizer
      平成30年度繊維学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 材料表面への分子修飾による機能材料の創出とその応用2018

    • Author(s)
      坂元 博昭
    • Organizer
      微細加工とその応用シンポ ジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 吸着タンパク質の2次構造/活性が保持されたポリウレタンナノファイバー基材2018

    • Author(s)
      森田祐子, 坂元博昭, 末信一朗
    • Organizer
      第27回インテリジェント材料/システムシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] ポリウレタンナノファイバー表面へのタンパク質吸着挙動の解析とその構造および活性変化の評価2017

    • Author(s)
      森田裕子, 坂元博昭,末信一朗
    • Organizer
      第69回日本生物工学会大会
    • Related Report
      2017 Research-status Report
  • [Book] 紛体の表面処理・複合化技術集大成 -基礎から応用まで-2018

    • Author(s)
      坂元 博昭, 末 信一朗
    • Total Pages
      752
    • Publisher
      テクノシステム
    • ISBN
      9784924728813
    • Related Report
      2018 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://ecnffukui.acbio.u-fukui.ac.jp/~lab/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 福井大学機能材料研究室ホームページ

    • URL

      http://ecnffukui.acbio.u-fukui.ac.jp/~lab/index.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 福井大学研究者総覧

    • URL

      http://t-profile.ad.u-fukui.ac.jp/profile/ja.facba8613e449286520e17560c007669.html

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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