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Is there shared neural underpinning of movement and social difficulties in autism spectrum disorders

Research Project

Project/Area Number 17K17766
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Childhood science (childhood environment science)
Special needs education
Research InstitutionWaseda University (2020-2021)
Advanced Telecommunications Research Institute International (2018-2019)
University of Fukui (2017)

Principal Investigator

OKAMOTO Yuko  早稲田大学, 高等研究所, 准教授(任期付) (10635139)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsfMRI / 自閉症 / 社会性 / コミュニケーション / 運動 / 身体知覚 / 個人差 / 発達 / 高次視覚野 / 自閉スペクトラム症 / 身体 / EBA / MRI / 身体認知 / 子ども / 教育系心理学 / 発達障害 / 脳画像研究
Outline of Final Research Achievements

Many autistic children, which have communication difficulty, show difficulties in movement, and motor and communication skills has been correlated. In this study, we used fMRI to measure the brain activity of autistic individuals while they were conducted body perception, body self-recognition, and reciprocal imitation tasks, and examined whether the activities were different from those of typically developing children and whether they were related to the some autistic characteristics. We reported that (1) the association between visual body representations and characteristics is more pronounced in children and is not observed in adulthood during body perception tasks, and (2) there are differences in activity in the higher visual cortex during body self-recognition tasks. In addition, developmental changes and individual differences within autism spectrum disorder and typical developmental individuals were observed.

Academic Significance and Societal Importance of the Research Achievements

これらの成果は、自閉スペクトラム症者における運動・社会性の障害の背景となる神経基盤を明らかにしたものであり、高次視覚野が両者に寄与していることを示す結果が得られた。一方で、さまざまな課題に一貫して、自閉スペクトラム症者・定型発達者の中で発達的な変化があることが明らかになり、また自閉スペクトラム症者や定型発達者の中での個人差も見つかっている。これらは自閉スペクトラム症のfMRI研究の知見を臨床に展開するにあたり、発達やheterogeneityを考慮する必要があることを示唆するものである。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (27 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (7 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 9 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Otago(ニュージーランド)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Otago(ニュージーランド)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Nanyang Technological University(シンガポール)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] University of Otago(ニュージーランド)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Importance of the early visual cortex and the lateral occipito-temporal cortex for the self-hand specific perspective process2021

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Kochiyama Takanori、Miyahara Motohide、Naruse Hiroaki、Sadato Norihiro、Okazawa Hidehiko、Kosaka Hirotaka
    • Journal Title

      Neuroimage: Reports

      Volume: 1 Issue: 4 Pages: 100046-100046

    • DOI

      10.1016/j.ynirp.2021.100046

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The extrastriate body area is involved in reciprocal imitation of hand gestures, vocalizations, and facial expressions: A univariate and multivariate fMRI study2021

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Tanabe Hiroki C.、Sasaki Akihiro T.、Kochiyama Takanori、Yahata Noriaki、Sadato Norihiro
    • Journal Title

      Social Neuroscience

      Volume: 16 Issue: 4 Pages: 448-465

    • DOI

      10.1080/17470919.2021.1944908

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 子どもの発達と自閉スペクトラム症の心理・脳科学研究2021

    • Author(s)
      岡本悠子
    • Journal Title

      発達精神医学研究所紀要

      Volume: 6 Pages: 54-60

    • Related Report
      2020 Research-status Report
  • [Journal Article] Attenuated activation of the anterior rostral medial prefrontal cortex on self-relevant social reward processing in individuals with autism spectrum disorder2020

    • Author(s)
      Sumiya Motofumi、Okamoto Yuko、Koike Takahiko、Tanigawa Tsubasa、Okazawa Hidehiko、Kosaka Hirotaka、Sadato Norihiro
    • Journal Title

      NeuroImage: Clinical

      Volume: - Pages: 102249-102249

    • DOI

      10.1016/j.nicl.2020.102249

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences between children and adults in functional connectivity between the inferior frontal gyrus and extrastriate body area for gestural interaction2020

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Seki Ayumi、Yanaka Hisakazu、Kochiyama Takanori、Koeda Tatsuya
    • Journal Title

      Social Neuroscience

      Volume: - Issue: 3 Pages: 1-13

    • DOI

      10.1080/17470919.2020.1717602

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visual body part representation in the lateral occipitotemporal cortex in children/adolescents and adults2020

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Kochiyama Takanori、Naruse Hiroaki、Makita Kai、Miyahara Motohide、Okazawa Hidehiko、Kosaka Hirotaka
    • Journal Title

      Cerebral cortex communications

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Local-to-distant development of the cerebrocerebellar sensorimotor network in the typically developing human brain: a functional and diffusion MRI study2019

    • Author(s)
      Amemiya Kaoru、Morita Tomoyo、Saito Daisuke N.、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Brain Structure and Function

      Volume: in press Issue: 3 Pages: 1359-1375

    • DOI

      10.1007/s00429-018-01821-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct sensitivities of the lateral prefrontal cortex and extrastriate body area to contingency between executed and observed actions2018

    • Author(s)
      Sasaki Akihiro T.、Okamoto Yuko、Kochiyama Takanori、Kitada Ryo、Sadato Norihiro
    • Journal Title

      Cortex

      Volume: 108 Pages: 234-251

    • DOI

      10.1016/j.cortex.2018.08.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder.2018

    • Author(s)
      Okamoto Y, Kitada R, Miyahara M, Kochiyama T, Naruse H, Sadato N, Okazawa H, Kosaka H.
    • Journal Title

      NeuroImage: Clinical

      Volume: in press. Pages: 384-395

    • DOI

      10.1016/j.nicl.2018.04.030

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Self-Face Recognition Begins to Share Active Region in Right Inferior Parietal Lobule with Proprioceptive Illusion During Adolescence2018

    • Author(s)
      Morita Tomoyo、Saito Daisuke N、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Cerebral Cortex

      Volume: 28 Issue: 4 Pages: 1532-1548

    • DOI

      10.1093/cercor/bhy027

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Right-hemispheric Dominance of Inferior Parietal Lobule in Proprioceptive Illusion Task2017

    • Author(s)
      Naito Eiichi、Morita Tomoyo、Saito Daisuke N、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru
    • Journal Title

      Cerebral Cortex

      Volume: 27 Issue: 11 Pages: 5385-5397

    • DOI

      10.1093/cercor/bhx223

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Visual Body Part Representation in the Lateral Occipitotemporal Cortex in Children/Adolescents and Adults2020

    • Author(s)
      Okamoto Yuko、Kitada Ryo、Kochiyama Takanori、Naruse Hiroaki、Makita Kai、Miyahara Motohide、Okazawa Hidehiko、Kosaka Hirotaka
    • Organizer
      日本神経科学学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 身体部位の脳内表象は大人と子どもで異なるか?2019

    • Author(s)
      岡本悠子、北田亮、 河内山隆紀、成瀬廣亮、宮原資英、牧田快、岡沢秀彦、小坂浩隆
    • Organizer
      日本心理学会大83回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 『ヒトにおいて他者とは何か?:自他認知において想定される階層的構造』 「自閉スペクトラム症における自他認知障害の階層性」2018

    • Author(s)
      岡本悠子
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Effective connectivity of the IFG and EBA depending on initiator and follower in gestural interaction on adults and children; a cross sectional study2018

    • Author(s)
      Y.Okamoto, A.Seki, R.Kitada, H.Yanaka, T.Kochiyama, T.Koeda
    • Organizer
      第41回日本神経科学学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Is this your hand or the hand of someone else?: An fMRI study on body awareness in autism spectrum disorder2017

    • Author(s)
      Okamoto Y, Kitada R, Miyahara M, Kochiyama T, Arai S, Ishikawa S, Sadato N, Okazawa H, Kosaka H
    • Organizer
      DCD12
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 子ども・大人の発達障害診療ハンドブック 年代別にみる症例と発達障害データ集2017

    • Author(s)
      内山登紀夫 (分担執筆:岡本悠子、小坂浩隆 [ASDの脳画像])
    • Total Pages
      360
    • Publisher
      中山書店
    • ISBN
      9784521745688
    • Related Report
      2017 Research-status Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/yokamoto

    • Related Report
      2021 Annual Research Report
  • [Remarks] https://researchmap.jp/yokamoto/

    • Related Report
      2018 Research-status Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/yokamoto/?lang=japanese

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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