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Cell type-specific epigenomic analysis of brain in a non-human primate model of depression

Research Project

Project/Area Number 17K17815
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Laboratory animal science
Research InstitutionShiga University of Medical Science

Principal Investigator

Hayashi Yoshitaka  滋賀医科大学, 医学部, 助教 (10631567)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大うつ病 / オリゴデンドロサイト / エピゲノム / 非ヒト霊長類 / カニクイザル / うつ病モデル
Outline of Final Research Achievements

In the postmortem study of brains from patients with major depression, we found the reduction of oligodendrocyte lineage cells specifically in the prefrontal cortex of the patient brains. We hypothesized that this abnormality is caused by epigenetic changes and conducted the current study. The number of proliferating oligodendrocyte lineage cells was measured in wild-type crab-eating macaque brains and found higher numbers in the prefrontal cortex and cingulate gyrus which have been suggested to be associated with psychiatric disorders. We analyzed the brains from depression models of crab-eating macaques established by chronically treated with interferon-alpha, and found DNA methylation abnormality in the Sox10 promoter in oligodendrocyte lineage cells.

Academic Significance and Societal Importance of the Research Achievements

2011年に厚生労働省が特に対策を進める5大疾患に精神疾患を加えたように、精神疾患の病態解明が期待されている。これまで、神経細胞を標的とした研究が多く行われてきており、一定の成果を上げているが、未だ病因の解明には至っていない。本研究では、オリゴデンドロサイト系譜細胞を標的とし、非ヒト霊長類を用いた研究により、病態解明を目指した。脳部位によってオリゴデンドロサイト系譜細胞の増殖数が異なることや、DNAメチル化変化を見出し、今後の病態解明に繋げたい。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results) Remarks (1 results)

  • [Journal Article] Life-Long Neural Stem Cells Are Fate-Specified at an Early Developmental Stage2020

    • Author(s)
      Tanaka Aoi、Ishida Shohei、Fuchigami Takahiro、Hayashi Yoshitaka、Kuroda Anri、Ikenaka Kazuhiro、Fukazawa Yugo、Hitoshi Seiji
    • Journal Title

      Cerebral Cortex

      Volume: 30 Issue: 12 Pages: 6415-6425

    • DOI

      10.1093/cercor/bhaa200

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult neurogenesis and its role in brain injury and psychiatric diseases2018

    • Author(s)
      Hayashi Yoshitaka、Jinnou Hideo、Sawamoto Kazunobu、Hitoshi Seiji
    • Journal Title

      Journal of Neurochemistry

      Volume: 147 Issue: 5 Pages: 584-594

    • DOI

      10.1111/jnc.14557

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集 大脳皮質-成り立ちから機能へ グリア細胞の分化・発生の時期と関連因子2017

    • Author(s)
      林 義剛, 等 誠司.
    • Journal Title

      生体の科学

      Volume: 68 Issue: 1 Pages: 24-28

    • DOI

      10.11477/mf.2425200568

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2017-02-15
    • Related Report
      2017 Research-status Report
  • [Presentation] Glial cells missing 1は損傷脳においてグリア細胞分化と血管新生を促進する.2020

    • Author(s)
      林 義剛, 福家 聡, 郷 康広, 中林 一彦, Adbullah Asmaa, Mohd Zakiyyah, 守村 直子, Daun Kenny, 小山 なつ, 等 誠司.
    • Organizer
      第63回日本神経化学会大会. 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Glial cells missing 1 promote cell differentiation and angiogenesis by growth factor expression.2019

    • Author(s)
      Yoshitaka Hayashi, Satoshi Fuke, Yasuhiro Go, Asmaa Abdullah, Takahiro Fuchigami, Naoko Morimura, Natsu Koyama, Seiji Hitoshi
    • Organizer
      2019 ASN-ISN
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Glial cells missing 1 は成長因子分泌を促進し、細胞の分化・増殖 および血管新生を誘導する2019

    • Author(s)
      Yoshitaka Hayashi, Satoshi Fuke, Yasuhiro Go, Kazuhiko Nakabayashi, Takahiro Fuchigami, Naoko Morimura, Natsu Koyama, Seiji Hitoshi
    • Organizer
      Neuro 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] Gcm1 regulates glial cell differentiation and angiogenesis in the mammalian brain2019

    • Author(s)
      Yoshitaka Hayashi
    • Organizer
      グリア研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Glial cells missing 1 promote cell differentiation and angiogenesis in the mammalian brain2019

    • Author(s)
      Yoshitaka Hayashi, Satoshi Fuke, Takahiro Fuchigami, Naoko Morimura, Natsu Koyama, Seiji Hitoshi
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Glial cells missing 1 promote cell differentiation, proliferation and angiogenesis in the mammalian brain2018

    • Author(s)
      Yoshitaka Hayashi
    • Organizer
      15th Meeting of Asian-Pacific Society for Neurochemistry
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The oligodendroglial abnormalities in the postmortem brain from human patients and monkey depression model2018

    • Author(s)
      Yoshitaka Hayashi, Yasuhiro Go, Natsu Koyama, Seiji Hitoshi
    • Organizer
      Towards Understanding “INDIVIDUALITY”
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Glial cells missing 1は損傷脳において 細胞分化・増殖と血管新生を促進する2018

    • Author(s)
      林義剛, 福家聡, 郷康広, 中林一彦, アスマビンティアブドゥラー, 渕上孝裕, 守村直子, 小山なつ, 等誠司
    • Organizer
      第15回成体脳ニューロン新生懇談会
    • Related Report
      2018 Research-status Report
  • [Presentation] The oligodendroglial abnormalities in the postmortem brain from human patients and monkey depression model.2017

    • Author(s)
      Yoshitaka Hayashi, Satoshi Fuke, Kazuhiko Nakabayashi, Takahiro Fuchigami, Naoko Morimura, Yoshitaka Tatebayashi, Seiji Hitoshi
    • Organizer
      ISN-ESN 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of Glial cell missing 1 in the mammalian brain.2017

    • Author(s)
      Yoshitaka Hayashi, Satoshi Fuke, Takahiro Fuchigami, Naoko Morimura, Natsu Koyama, Seiji Hitoshi
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Research-status Report
  • [Remarks] 滋賀医科大学 生理学講座 統合臓器生理学部門 ホームページ

    • URL

      http://www.shiga-med.ac.jp/~hqphysi1/

    • Related Report
      2018 Research-status Report 2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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