Analysis of the molecular mechanism to repair acetaldehyde-induced DNA damage
| Project/Area Number |
17K17846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
Molecular biology
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| Research Institution | Kindai University (2019)
Osaka University (2017-2018) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 相同組換え / アセトアルデヒド / ICL修復 / ゲノム / 癌 |
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| Outline of Final Research Achievements |
As a consequence of the analysis of acetaldehyde-induced DNA damage, we found novel regulatory factors of homologous recombination, SWSAP1 and FIGNL1. We also revealed FIGNL1 has an activity to prevent homologous recombination. In addition, the regulation by these proteins is essential for spermatogenesis and oogenesis in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
相同組換えは、異なる染色体同士を組換える機構である。これまでに、飲酒によって生じるアセトアルデヒド依存的なDNA損傷の修復に相同組換えが関与する可能性が示されてきた。本研究では、アセトアルデヒによるDNA損傷の解析を行なった結果、新規の相同組換え制御因子を発見した。本研究で発見した相同組換え制御因子は、既存の制御因子と全く異なる方法で相同組換えを制御しており、新しい相同組換え制御メカニズムを提唱することができた。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] A. Shinohara, Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPase.2019
Author(s)
Matsuzaki, K., Kondo, S., Ishikawa, T., and A. Shinohara,
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Journal Title
Nature Communications
Volume: 10
Issue: 1
Pages: 1407-1407
DOI
Related Report
Peer Reviewed / Open Access
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