• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Can the fatal lung injury be improved by administering neutrophil elastase inhibitor ?

Research Project

Project/Area Number 17K17890
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Medical Physics and Radiological Technology
Research InstitutionShimane University

Principal Investigator

Tamaki Yukihisa  島根大学, 学術研究院医学・看護学系, 准教授 (40457099)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords放射線防護 / 肺癌 / 放射線肺障害 / 放射線障害 / 放射線肺臓炎 / 好中球エラスターゼ阻害剤
Outline of Final Research Achievements

Both lungs of the mice were irradiated once with 12 Gy, and 6 hours later, a neutrophil elastase inhibitor (NEI) was intraperitoneally administered, and the effect was examined. There was no significant difference in body weight (g) and lung weight (g / g) per body weight 1 day after irradiation among the three groups: control group, irradiation group, and NEI administration group after irradiation.
Next, immunostaining with the neutrophil antibody Ly6G was performed, and positive cells were quantified by image J. As a result, there was no significant differencet among the three groups.
In addition, the mRNA expression of peripheral neutrophil marker protein Ly6G, macrophage marker protein F4/80, cytokine IL-1β, and IL-6 was compared by real-time PCR. However, no significant difference was observed among the three groups.

Academic Significance and Societal Importance of the Research Achievements

今回の結果では有意差は認められなかったが、今後の課題として照射線量を多くしたり、あるいは1日後の評価でなく数日後の評価で行うことなどが挙げられる。
放射線肺障害の病態は依然として解明されておらず、これからもこれらの課題を生かしながら、研究方法や材料を工夫しながら、引き続き研究に取り組んでいく。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi