Pathogenesis of IgG4-related disease: disease developing mechanism by specific antigen
| Project/Area Number |
17K17894
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
Immunology
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| Research Institution | Kurume University (2018-2019)
Okayama University (2017) |
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Principal Investigator |
Takeuchi Mai 久留米大学, 医学部, 助教 (10759666)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | IgG4関連疾患 / 樹状細胞 / リンパ球 / 遺伝子発現解析 / 免疫 / キャッスルマン病 / リンパ節 / 免疫応答 / 病理学 / アレルギー・ぜんそく |
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| Outline of Final Research Achievements |
Langerhans cell-like dendritic cells were significantly increased in IgG4-related disease involving salivary glands in our previoud study. We hypothesized that certain specific antigens stimulated these dendritic cells to cause IgG4-related disease. Although we tried to investigate peripheral blood of patients, we changed our plan because the representative researcher moved to other institution. Instead, we planned comprehensive gene expression analysis using nCounter method. Although COVID-19 interrupted the analysis, we will finish the analysis shortly and publish the results at academic meeting and journals.
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| Academic Significance and Societal Importance of the Research Achievements |
IgG4関連疾患は原因不明の腫瘤形成性疾患であり難病指定を受けている。治療の第一選択はステロイドであるが、ステロイドの長期投与による副作用やステロイド中断後の再燃が問題となる他、ステロイド無効例に対する治療も課題となっている。本研究でIgG4関連疾患の病態が解明されれば、より効果的な治療開発の一助となることが期待される。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Comprehensive Immunohistochemical Analysis of Immune Checkpoint Molecules in Adult T Cell Leukemia/Lymphoma2020
Author(s)
Takeuchi M, Miyoshi H, Nakashima T, Kawamoto K, Yamada K, Yanagida E, Muta H, Moritsubo M, Umeno T, Suzuki T, Seto M, Ohshima K.
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Journal Title
Annals of Hematology
Volume: 99
Issue: 5
Pages: 1093-1098
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Human leukocyte antigen class II expression is a good prognostic factor of adult T-cell leukemia/lymphoma.2019
Author(s)
Mai Takeuchi, Hiroaki Miyoshi, Naoko Asano, Noriaki Yoshida, Kyohei Yamada, Eriko Yanagida, Mayuko Moritsubo, Michiko Nakata, Takeshi Umeno, Takaharu Suzuki, Satoru Komaki, Hiroko Muta, Takuya Furuta, Masao Seto, Koichi Ohshima
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Journal Title
Haematologica
Volume: 印刷中
Issue: 8
Pages: 1626-1632
DOI
Related Report
Peer Reviewed / Open Access
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