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Pathogenesis of IgG4-related disease: disease developing mechanism by specific antigen

Research Project

Project/Area Number 17K17894
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Immunology
Research InstitutionKurume University (2018-2019)
Okayama University (2017)

Principal Investigator

Takeuchi Mai  久留米大学, 医学部, 助教 (10759666)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsIgG4関連疾患 / 樹状細胞 / リンパ球 / 遺伝子発現解析 / 免疫 / キャッスルマン病 / リンパ節 / 免疫応答 / 病理学 / アレルギー・ぜんそく
Outline of Final Research Achievements

Langerhans cell-like dendritic cells were significantly increased in IgG4-related disease involving salivary glands in our previoud study. We hypothesized that certain specific antigens stimulated these dendritic cells to cause IgG4-related disease. Although we tried to investigate peripheral blood of patients, we changed our plan because the representative researcher moved to other institution. Instead, we planned comprehensive gene expression analysis using nCounter method. Although COVID-19 interrupted the analysis, we will finish the analysis shortly and publish the results at academic meeting and journals.

Academic Significance and Societal Importance of the Research Achievements

IgG4関連疾患は原因不明の腫瘤形成性疾患であり難病指定を受けている。治療の第一選択はステロイドであるが、ステロイドの長期投与による副作用やステロイド中断後の再燃が問題となる他、ステロイド無効例に対する治療も課題となっている。本研究でIgG4関連疾患の病態が解明されれば、より効果的な治療開発の一助となることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] Comprehensive Immunohistochemical Analysis of Immune Checkpoint Molecules in Adult T Cell Leukemia/Lymphoma2020

    • Author(s)
      Takeuchi M, Miyoshi H, Nakashima T, Kawamoto K, Yamada K, Yanagida E, Muta H, Moritsubo M, Umeno T, Suzuki T, Seto M, Ohshima K.
    • Journal Title

      Annals of Hematology

      Volume: 99 Issue: 5 Pages: 1093-1098

    • DOI

      10.1007/s00277-020-03967-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human leukocyte antigen class II expression is a good prognostic factor of adult T-cell leukemia/lymphoma.2019

    • Author(s)
      Mai Takeuchi, Hiroaki Miyoshi, Naoko Asano, Noriaki Yoshida, Kyohei Yamada, Eriko Yanagida, Mayuko Moritsubo, Michiko Nakata, Takeshi Umeno, Takaharu Suzuki, Satoru Komaki, Hiroko Muta, Takuya Furuta, Masao Seto, Koichi Ohshima
    • Journal Title

      Haematologica

      Volume: 印刷中 Issue: 8 Pages: 1626-1632

    • DOI

      10.3324/haematol.2018.205567

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease.2019

    • Author(s)
      Gion Y, Takeuchi M, Shibata R, Takata K, Miyata-Takata T, Orita Y, Tachibana T, Yoshino T, Sato Y
    • Journal Title

      Scientific Report

      Volume: 9 Issue: 1 Pages: 761-761

    • DOI

      10.1038/s41598-018-37404-x

    • NAID

      120006777520

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ocular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease2016

    • Author(s)
      Nishida K, Sogabe Y, Makihara A, Senoo A, Morimoto H, Takeuchi M, Gion Y, Yoshino T, Sato Y
    • Journal Title

      Modern Rheumatology

      Volume: epub Issue: 2 Pages: 383-387

    • DOI

      10.1080/14397595.2016.1216733

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] HLA class II発現は成人T細胞白血病/リンパ腫の予後因子である2019

    • Author(s)
      竹内真衣、三好寛明、浅野直子、山田恭平、柳田恵理子、森坪麻友子、牟田紘子、古田拓也、瀬戸加大、大島孝一
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] POEMS症候群の病理2018

    • Author(s)
      竹内真衣
    • Organizer
      キャッスルマン病・TAFRO症候群・IgG4関連疾患・POEMS症候群4疾患合同検討会議
    • Related Report
      2018 Research-status Report
  • [Presentation] DLBCLにおけるHLA発現と免疫微小環境の検討2018

    • Author(s)
      竹内真衣、三好寛明、宮脇恒太、大島孝一
    • Organizer
      平成30年度難治性リンパ腫小班(山口班)班会議
    • Related Report
      2018 Research-status Report
  • [Presentation] DLBCLにおけるHLAと免疫微小環境の検討2018

    • Author(s)
      竹内真衣、三好寛明、宮脇恒太、大島孝一
    • Organizer
      第4回リンパ腫分子病態研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] リンパ節の病理2018

    • Author(s)
      竹内真衣
    • Organizer
      第41回日本乳腺甲状腺超音波学会
    • Related Report
      2018 Research-status Report
  • [Presentation] IgG4関連疾患におけるランゲルハンス細胞様樹状細胞による抗原提示の可能性2017

    • Author(s)
      竹内真衣、祇園由佳、林詠子、井川卓朗、佐藤康晴、吉野正
    • Organizer
      リンパ網内系学会
    • Related Report
      2017 Research-status Report
  • [Presentation] IgG4関連唾液腺症の上皮におけるランゲルハンス細胞様樹状細胞を介した抗原提示の可能性2017

    • Author(s)
      竹内真衣、佐藤康晴、祇園由佳、林詠子、吉野正
    • Organizer
      日本病理学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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