| Project/Area Number |
17K17916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
Cell biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Guo Yun 広島大学, 医歯薬保健学研究科(医), 助教 (50609766)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | A20 / thymic selection / 免疫学 |
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| Outline of Final Research Achievements |
Thymic selection decides the T cell fate; therefore it decides our body to be healthy or sick. However, the mechanism that underlies the regulation of thymic selection is still poorly understood. A20, also known as TNFAIP3, is a ubiquitin - modifying enzyme and related with multiple autoimmune and inflammatory diseases. In this study, we used A20 T-cell specific deficient mice to examine the role of A20 in thymic selection.
As a result, 1) We found that A20 plays an important role in thymic selection to decide the T cell fate, like increased Treg cells, reduced iNKT and nIEL subsets in A20 deficient mice. 2) The increase of Treg cells in A20 deficient mice was related with the changed TCR signal. 3)We examined the role of A20 deficient T cells in body, and found that loss of A20 in T cell will impair antitumor immunity and reduce the severity of the EAE induction in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
Knowledge gained from this study will significantly improve our understanding of T cell biology, and will provide important information to advance the design of novel cell-based therapies for human cancer and autoimmune diseases as well as allergenic response.
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