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The comprehensive identification of transcription factors associated with anti-atherosclerotic effects of polyphenols and the clarification of the mechanisms

Research Project

Project/Area Number 17K17923
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

KANOH Naomi  徳島大学, 大学院医歯薬学研究部(医学域), 助教 (30780267)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords機能性食品成分 / ポリフェノール / 動脈硬化 / 転写因子 / スクリーニング / マクロファージ / TMT解析 / 2D-DIGE / プロテオーム解析
Outline of Final Research Achievements

We comprehensively identified the transcription factors associated with anti-atherosclerotic effects of polyphenols using the Tandem Mass Tag analysis. The oxidized LDL decreased and several polyphenols (resveratrol, piceid, hesperetin and eriodictiol) increased the protein level in nuclear of FoxM1, one of the identified transcription factors. Furthermore, the oxidized LDL decreased and resveratrol, piceid, hesperetin and eriodictiol increased the gene expression of MFG-E8 and efferocytosis activity, both contribute to the suppression of atherosclerosis.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた結果は、ポリフェノールの抗動脈硬化作用の科学的な根拠を提供し、新規の分子基盤に基づいた機能性食品の開発に貢献することが期待される。また、本研究で確立したシグナル関連転写因子の網羅的同定システムは、転写因子間のクロストークの発見による遺伝子発現の新規制御機構の解明を含む新たなシグナル伝達機構の解明に貢献することが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells2019

    • Author(s)
      Naomi Kanoh, Yumi Kunimoto, Daisuke Takemoto, Yoshiko Ono, Hiroshi Shibata, Kohta Ohnishi and Yoshichika Kawai
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 67 Issue: 27 Pages: 7640-7649

    • DOI

      10.1021/acs.jafc.8b07227

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells2018

    • Author(s)
      Tang Yue、Naito Sho、Abe-Kanoh Naomi、Ogawa Seiji、Yamaguchi Shu、Zhu Beiwei、Murata Yoshiyuki、Nakamura Yoshimasa
    • Journal Title

      Journal of Biochemical and Molecular Toxicology

      Volume: なし Issue: 6

    • DOI

      10.1002/jbt.22054

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physiological relevance of covalent protein modification by dietary isothiocyanates2018

    • Author(s)
      Nakamura Toshiyuki、Abe-Kanoh Naomi、Nakamura Yoshimasa
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 1 Pages: 11-19

    • DOI

      10.3164/jcbn.17-91

    • NAID

      130006301253

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells2017

    • Author(s)
      Liu Xiaoyang、Takano Chiaki、Shimizu Tomomi、Yokobe Shintaro、Abe-Kanoh Naomi、Zhu Beiwei、Nakamura Toshiyuki、Munemasa Shintaro、Murata Yoshiyuki、Nakamura Yoshimasa
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 491 Issue: 1 Pages: 209-216

    • DOI

      10.1016/j.bbrc.2017.07.078

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Benzyl isothiocyanate ameliorates acetaldehyde-induced cytotoxicity by enhancing aldehyde dehydrogenase activity in murine hepatoma Hepa1c1c7 cells2017

    • Author(s)
      Liu Yujia、Yamanaka Momoko、Abe-Kanoh Naomi、Liu Xiaoyang、Zhu Beiwei、Munemasa Shintaro、Nakamura Toshiyuki、Murata Yoshiyuki、Nakamura Yoshimasa
    • Journal Title

      Food and Chemical Toxicology

      Volume: 108 Pages: 305-313

    • DOI

      10.1016/j.fct.2017.08.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells2017

    • Author(s)
      Liu Xiaoyang、Abe-Kanoh Naomi、Liu Yujia、Zhu Beiwei、Munemasa Shintaro、Nakamura Toshiyuki、Murata Yoshiyuki、Nakamura Yoshimasa
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 11 Pages: 2212-2215

    • DOI

      10.1080/09168451.2017.1374830

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] The effects of resveratrol and piceid on macrophage efferocytosis2019

    • Author(s)
      Naomi Kanoh, Yuki Hashimoto, Haruka Yamamoto and Miyuki Uemura
    • Organizer
      ICoFF2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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