Investigation of physiological functions of epigenetic regulator Uhrf1 in rheumatoid arthritis
| Project/Area Number |
17K17929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
Integrative animal science
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| Research Institution | Ehime University |
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Principal Investigator |
SAEKI NORITAKA 愛媛大学, 学術支援センター, 助教 (80791607)
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| Research Collaborator |
Imai Yuuki
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節リウマチ / 滑膜線維芽細胞 / エピジェネティクス / Uhrf1 / 炎症性サイトカイン / 自己免疫疾患 / 滑膜マクロファージ / 細胞・組織 / シグナル伝達 |
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| Outline of Final Research Achievements |
In rheumatoid arthritis, epigenetic regulatory mechanisms in synovial cells are largely unknown. We have tried to explore epigenetic regulator and its molecular functions that contribute to the progression of rheumatoid arthritis. We found that epigenetic regulator Uhrf1 was significantly increased in arthritis tissue and expressed in synovial fibroblasts. In addition, our results indicated that Uhrf1 in synovial fibroblasts suppressed expressions of cytokines-related genes and regulated arthritis progression negatively.
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| Academic Significance and Societal Importance of the Research Achievements |
現在、関節リウマチ治療において生物学的製剤が奏功しているが、これらは単一の増悪因子に対する阻害剤であり、十分な効果が認められないケースも報告されている。これまでの研究成果より、滑膜線維芽細胞に発現するUhrf1はいくつかの関節リウマチ増悪因子の発現を網羅的に制御している可能性が示唆されている。関節リウマチ患者の滑膜線維芽細胞でUhrf1発現を上昇させる、あるいは安定化させることができれば、既存の治療薬よりも高い効果が得られるかもしれない。
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Report
(3 results)
Research Products
(11 results)
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[Presentation] Epigenetic regulator, Uhrf1, positively controls skeletal muscle differentiation2018
Author(s)
Yuichiro Sawada, Tadahiko Kikugawa, Iori Sakakibara, Yusuke Ono, Yuta Yanagihara, Noritaka Saeki, Hiroyuki Iio, Takashi Saika, Yuuki Imai
Organizer
The American Society for Bone and Mineral Research 2018 Annual Meeting
Related Report
Int'l Joint Research
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