Metagenomic approach for within-host genomic diversity in bacteremia
| Project/Area Number |
17K17933
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
Bacteriology (including mycology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 遺伝的多様性 / 菌血症 / メタゲノム / 患者内多様性 / ヘテロサイト / ハプロタイプ / メタゲノム解析 / クローン / 細菌ゲノム |
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| Outline of Final Research Achievements |
Diagnosis of bacteremia is performed by identification of bacterial pathogen using blood culture technique and single colony isolation. However, the causative bacteria present in the patient are not necessarily single clone. It is possible that some genetic diversity exists, and further changes will be occurred by treatment or host immunity. In this study, we performed population genetics and metagenomic analysis to reveal the genetic diversity of the causative bacteria present in individual patients and their variation in cases of bacteremia.
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| Academic Significance and Societal Importance of the Research Achievements |
菌血症を発症した血液中の病原細菌を集団として捉えて、集団遺伝学的な視点から、その遺伝的多様性を解析するという新しい発想に基づく研究であり、特定の分離菌株のみを対象とする従来の解析では得られなかった菌血症の発症・進展に係わる新たな知見が得られた。
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Report
(3 results)
Research Products
(7 results)
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[Presentation] 院内感染疑い事例の全ゲノムシーケンスによる超高解像度分子疫学解析2019
Author(s)
後藤恭宏, 谷口喬子, 吉村大, 桂啓介, 佐伯裕二, 平原康寿, 福田真弓, 高城一郎, 小椋義俊, 伊藤武彦, 三澤尚明, 岡山昭彦, 林哲也
Organizer
第13回日本ゲノム微生物学会
Related Report
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