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Noise induced synchronization of circadian rhythms

Research Project

Project/Area Number 17K17946
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biophysics
Biological physics/Chemical physics/Soft matter physics
Research InstitutionKyushu University

Principal Investigator

Ito Hiroshi  九州大学, 芸術工学研究院, 准教授 (20512627)

Research Collaborator Murayama yoriko  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywordsシアノバクテリア / 概日リズム / ノイズ / ノイズ同期 / ノイジーな刺激
Outline of Final Research Achievements

Noise induced synchronization by random pulsed dark was not observed when we expose 1 hour, 2 hours, and 3 hours dark to bacteria on solid medium nor liquid medium. Thus, the noisy component contained in natural light condition does not seems to play any role in the synchronization of circadian rhythm.
The difficulty of noise synchronization suggests that the circadian rhythm in organisms is robust against noisy stimulation with a few hours. Based on this observation, it is expected that the noisy stimulus component in the natural environment does not cause synchronization phenomenon. This suggests that the circadian rhythms are robustly kept even in complex and noisy ambient conditions.

Academic Significance and Societal Importance of the Research Achievements

今回の結果は体内時計が外部のランダムな暗黒ノイズに抗して正確に刻み続けることを示している。また、追加で実験した温度に対しては、振幅が比較的鋭敏に反応することがわかった。さらに今回発見した概日リズム共鳴現象を応用して、私たちの体内時計の振れ幅を増加させることが可能になるかもしれない。例えば生活リズム障害の方に対して、メリハリのついたリズムをとりもどす知見を与える可能性がある。またサイエンスの観点では「体内時計が減衰振動子に容易に変わりうる」という生物学的に新規な知見をもたらした。減衰振動は、体内時計研究において開拓されるべき新天地となりうる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 3 results) Remarks (2 results)

  • [Int'l Joint Research] Universite Grenoble Alpes(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Universite Grenoble Alpes(France)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation2017

    • Author(s)
      Murayama Yoriko、Kori Hiroshi、Oshima Chiaki、Kondo Takao、Iwasaki Hideo、Ito Hiroshi
    • Journal Title

      PNAS

      Volume: 114 Issue: 22 Pages: 5641-5646

    • DOI

      10.1073/pnas.1620378114

    • NAID

      120006220445

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 概日リズムと温度に関する理論的研究または落ちこぼれの時間生物学2018

    • Author(s)
      伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Chronobiology based on amplitude2018

    • Author(s)
      伊藤浩史
    • Organizer
      時間生物学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 振幅からみた時間生物学2018

    • Author(s)
      Hiroshi Ito
    • Organizer
      Cyano Clock 1,0
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Loss of circadian rhythm of Aradidopsis thaliana under low temperature via Hopf bifurcation2017

    • Author(s)
      Haruki Yamasaki, Takiko Kouzuma, Hiroshi Ito
    • Organizer
      時間生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Resonance of low-temperature-induced damped circadian oscillation in cyanobacteria2017

    • Author(s)
      Shohei Oda, Hiroshi Ito
    • Organizer
      時間生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Excitable system of chromatophores in Uroteuthis eulis2017

    • Author(s)
      Ryo Adachi, Hiroshi Ito
    • Organizer
      時間生物学会年会
    • Related Report
      2017 Research-status Report
  • [Remarks] 伊藤浩史研究室

    • URL

      http://www.design.kyushu-u.ac.jp/~hito/index.php?Ito%20Lab%20%20%E4%BC%8A%E8%97%A4%E7%A0%94%E7%A9%B6%E5%AE%A4

    • Related Report
      2018 Annual Research Report
  • [Remarks] 伊藤研究室

    • URL

      http://www.design.kyushu-u.ac.jp/~hito/

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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