Elucidation of the articular cartilage degeneration cascade caused by joint instability

• Project/Area Number: 17K17984
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Rehabilitation science/Welfare engineering
• Research Institution: Saitama Prefectural University
• Principal Investigator: Murata Kenji 埼玉県立大学, 保健医療福祉学部, 助教 (30792056)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 変形性膝関節症 / 関節不安定性 / 関節軟骨 / TGF-β / smad2/3 / 滑膜 / 骨棘 / メカニカルストレス / smadシグナリング / 軟骨 / 変形性関節症

Outline of Final Research Achievements

Articular cartilage is maintained in balance between the breakdown and synthesis of cartilage tissue. Previous studies have shown that joint instability is a key factor in the prevention of the onset and progression of knee osteoarthritis. Moreover, inflammatory cytokines and chondrocyte-degrading enzymes, which contribute to the degradation of cartilage were suppressed in inhibited joint instability models

Academic Significance and Societal Importance of the Research Achievements

変形性膝関節症は国内でも罹患者の多い運動器疾患であるが、その原因や対処法については不明瞭な点も多い。そのなかで、関節不安定性に着目し、関節不安定性がメカニカルストレスの一要因として、軟骨変性を引き起こす可能性を報告した。このことは、関節のぐらつきを止めることで軟骨変性を抑制できる可能性を示し、今後のリハビリテーション分野における治療指針や予防方法を考える上で一助となることとが期待される

Research Products

• [Journal Article] Controlling joint instability after anterior cruciate ligament transection inhibits transforming growth factor-beta-mediated osteophyte formation (2019)
  • Author(s): Murata K, Kokubun T, Onitsuka K, Oka Y, Kano T, Morishita Y, Ozone K, Kuwabara N, Nishimoto J, Isho T, Takayanagi K, Kanemura N
  • Journal Title: Osteoarthritis and Cartilage Volume: 27(8) Issue: 8 Pages: 1185-1196
  • DOI: 10.1016/j.joca.2019.03.008
  • Peer Reviewed
• [Journal Article] Restoring knee joint kinematics after anterior cruciate ligament injury might inhibit synovial membrane inflammation. (2018)
  • Author(s): Murata K, Kokubun T, Takayanagi K, Kanemura N
  • Journal Title: Sport Sciences for Health Volume: 13 Issue: 1 Pages: 113-119
  • DOI: 10.1007/s11332-018-0481-y
  • Peer Reviewed
• [Presentation] CONTROLLING JOINT INSTABILITY AFTER ANTERIOR CRUCIATE LIGAMENT TRANSECTION INHIBITS THE TRANSFORMING GROWTH FACTOR-BETA-MEDIATED OSTEOPHYTE FORMATION (2020)
  • Author(s): K. Murata, Y. OKa, K. Onitsuka, T. Kokubun, A. Nakajima, K. Arakawa, S. Nakagaki, N. Kenamura.
  • Organizer: Osteoarthritis Research Society International2020 World Congress （Postponement for COVIT-19）
• [Presentation] 変形性膝関節症動物モデルにおける関節運動の正常化がBMP-2/Smad mRNA発現量に及ぼす影響 (2018)
  • Author(s): 村田健児, 岡優一郎, 加納拓馬, 国分貴徳, 鬼塚勝哉, 森下佑里, 小曽根海知, 桑原希望, 西元淳司, 藤原秀平, 中島彩, 高柳清美, 金村尚彦
  • Organizer: 第37回関東甲信越ブロック理学療法士学会
• [Book] 関節不安定性が関節構成体に及ぼすメカノセンシング (2019)
  • Author(s): 村田健児, 国分貴徳, 金村尚彦
  • Publisher: 月刊細胞 （北隆館ニューサイエンス社）