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The predictive model adjusted with gene-environment interaction on clinical outcomes in patienst with head and neck cancer

Research Project

Project/Area Number 17K18006
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Hygiene and public health
Research InstitutionNagoya City University

Principal Investigator

Daisuke Kawakita  名古屋市立大学, 医薬学総合研究院(医学), 講師 (70584506)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頭頸部がん / HPV / DNA修復酵素 / 遺伝環境交互作用 / 予後 / ヒト乳頭腫ウイルス抗体価 / 遺伝子多型
Outline of Final Research Achievements

The aim of this study is to establish the predictive model adjusted with gene-environment interaction on clinical outcomes in patients with head and neck cancer using epidemiological approach. First, we have expanded our head and neck cancer patient cohort (1,099 cases), and extracted DNA from the buffy coat fraction in 106 cases with oropharyngeal cancer. Next, we have examined p16 status in patients with oropharyngeal cancer using paraffin-embedded tissue sample. As for genetic polymorphisms in DNA repair gene, we continue to investigate whether which genetic polymorphisms in DNA repair gene are associated with clinical outcomes in patients with head and neck cancer.

Academic Significance and Societal Importance of the Research Achievements

これまでの疫学研究は予防に重点が置かれており、予後への影響を検討した研究は限られている。疫学手法を用いて、生活習慣・遺伝的因子の頭頸部がん生存への影響について検討することは、個別化頭頸部がん予後予測モデルの構築において重要と考える。疫学研究は得られた知見が臨床への早期の応用が可能であること(禁煙、節酒など)などが特徴に挙げられ、早期の介入効果が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (62 results)

All 2020 2019 2018 2017

All Journal Article (24 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (38 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] 【知っておくべき耳鼻咽喉科領域における医薬品副作用】抗がん薬(解説/特集)2020

    • Author(s)
      川北大介、的場拓磨
    • Journal Title

      ENTONI

      Volume: 240 Pages: 15-20

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Body mass index and the risk of head and neck cancer in the Chinese population2019

    • Author(s)
      Chen Yuji、Lee Yuan-Chin Amy、Li Shuang、Li Qian、Chen Chien-Jen、Hsu Wan-Lun、Lou Pen-Jen、Zhu Cairong、Pan Jian、Shen Hongbing、Ma Hongxia、Cai Lin、He Baochang、Wang Yu、Zhou Xiaoyan、Ji Qinghai、Zhou Baosen、Wu Wei、Ma Jie、Kawakita Daisuke、Boffetta Paolo、Zhang Zuo-Feng、Dai Min、Hashibe Mia
    • Journal Title

      Cancer Epidemiology

      Volume: 60 Pages: 208-215

    • DOI

      10.1016/j.canep.2019.04.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Oncolytic activity of HF10 in head and neck squamous cell carcinomas2019

    • Author(s)
      Esaki Shinichi、Goshima Fumi、Ozaki Haruka、Takano Gaku、Hatano Yoshimi、Kawakita Daisuke、Ijichi Kei、Watanabe Takahiro、Sato Yoshitaka、Murata Takayuki、Iwata Hiromitsu、Shibamoto Yuta、Murakami Shingo、Nishiyama Yukihiro、Kimura Hiroshi
    • Journal Title

      Cancer Gene Therapy

      Volume: - Issue: 7-8 Pages: 585-598

    • DOI

      10.1038/s41417-019-0129-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study2019

    • Author(s)
      Kawakita Daisuke、Abdelaziz Sarah、Chen Yuji、Rowe Kerry、Snyder John、Fraser Alison、Smith Ken、Herget Kimberly、Deshmukh Vikrant、Newman Michael、Monroe Marcus、Hashibe Mia
    • Journal Title

      Cancer

      Volume: 126 Issue: 4 Pages: 879-885

    • DOI

      10.1002/cncr.32617

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 乳頭癌と髄様癌の甲状腺衝突癌例2019

    • Author(s)
      黒田陽、的場拓磨、高野学、小栗恵介、村嶋明大、岩城翔、村上信五、川北大介
    • Journal Title

      耳鼻咽喉科臨床

      Volume: 112(9) Pages: 603-608

    • NAID

      130007699728

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 再発・転移頭頸部癌に対するCBDCA+PTX療法の治療成績2019

    • Author(s)
      岩城翔、川北大介、小栗恵介、村嶋明大、的場拓磨、高野学、澤部倫、村上信五
    • Journal Title

      頭頸部癌

      Volume: 45(4) Pages: 420-425

    • NAID

      130007851708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鼻腔に発生した胞巣性軟部肉腫の一例2019

    • Author(s)
      佐藤雄二、三好晋平、川北大介、村上信五
    • Journal Title

      耳鼻と臨床

      Volume: 65(6) Pages: 186-189

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiber intake and the risk of head and neck cancer in the prostate, lung, colorectal and ovarian (PLCO) cohort2019

    • Author(s)
      Kawakita Daisuke、Lee Yuan-Chin Amy、Gren Lisa H.、Buys Saundra S.、La Vecchia Carlo、Hashibe Mia
    • Journal Title

      International Journal of Cancer

      Volume: 印刷中 Issue: 9 Pages: 2342-2348

    • DOI

      10.1002/ijc.32162

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.2019

    • Author(s)
      Matoba T, Imai M, Ohkura N, Kawakita D, Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S.
    • Journal Title

      International Journal of Cancer

      Volume: 144(11) Issue: 11 Pages: 2811-2822

    • DOI

      10.1002/ijc.32024

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2 Positive Salivary Duct Carcinoma2019

    • Author(s)
      Takahashi Hideaki、Tada Yuichiro、Saotome Takashi、Akazawa Kohei、Ojiri Hiroya、Fushimi Chihiro、Masubuchi Tatsuo、Matsuki Takashi、Tani Kaori、Osamura Robert Y.、Hirai Hideaki、Yamada Shuhei、Kawakita Daisuke、Miura Kouki、Kamata Shin-etsu、Nagao Toshitaka
    • Journal Title

      Journal of Clinical Oncology

      Volume: 37 Issue: 2 Pages: 125-134

    • DOI

      10.1200/jco.18.00545

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Processed meat and risk of selected digestive tract and laryngeal cancers.2019

    • Author(s)
      Rosato V, Kawakita D, Negri E, Serraino D, Garavello W, Montella M, Decarli A, La Vecchia C, Ferraroni M.
    • Journal Title

      European Journal of Clinical Nutrition

      Volume: 73(1) Issue: 1 Pages: 141-149

    • DOI

      10.1038/s41430-018-0153-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The high expression of FOXA1 is correlated with a favourable prognosis in salivary duct carcinomas: a study of 142 cases2018

    • Author(s)
      Urano Makoto、Hirai Hideaki、Tada Yuichiro、Otsuka Kuninori、Watanabe Yoshihiro、Sakai Akihiro、Ebisumoto Koji、Togashi Takafumi、Ueki Yushi、Ota Hisayuki、Sato Yukiko、Saigusa Natsuki、Nakaguro Masato、Hanazawa Toyoyuki、Nagao Toshitaka
    • Journal Title

      Histopathology

      Volume: 73 Issue: 6 Pages: 943-952

    • DOI

      10.1111/his.13706

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation analysis of the EGFR pathway genes, EGFR, RAS, PIK3CA, BRAF, and AKT1, in salivary gland adenoid cystic carcinoma.2018

    • Author(s)
      Saida K, Murase T, Ito M, Fujii K, Takino H, Masaki A, Kawakita D, Ijichi K, Tada Y, Kusafuka K,Iida Y, Onitsuka T, Yatabe Y, Hanai N, Hasegawa Y
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 24 Pages: 17043-17055

    • DOI

      10.18632/oncotarget.24818

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The impact of folate intake on the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort.2018

    • Author(s)
      Kawakita D, Lee YA, Gren LH, Buys SS, La Vecchia C, Hashibe M.
    • Journal Title

      British Journal of Cancer

      Volume: 118(2) Issue: 2 Pages: 299-306

    • DOI

      10.1038/bjc.2017.383

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study.2018

    • Author(s)
      Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y
    • Journal Title

      Cancer.

      Volume: 124 Issue: 1 Pages: 118-124

    • DOI

      10.1002/cncr.30957

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma2017

    • Author(s)
      Fushimi C、Tada Y、Takahashi H、Nagao T、Ojiri H、Masubuchi T、Matsuki T、Miura K、Kawakita D、Hirai H、Hoshino E、Kamata S、Saotome T
    • Journal Title

      Annals of Oncology

      Volume: 29 Issue: 4 Pages: 979-984

    • DOI

      10.1093/annonc/mdx771

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas2017

    • Author(s)
      Shimura Tomotaka、Tada Yuichiro、Hirai Hideaki、Sato Yukiko、et al.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 2 Pages: 1852-1867

    • DOI

      10.18632/oncotarget.22927

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemo-selection with docetaxel, cisplatin and 5-fluorouracil (TPF) regimen followed by radiation therapy or surgery for pharyngeal and laryngeal carcinoma.2017

    • Author(s)
      Matoba T, Ijichi K, Yanagi T, Kabaya K, Kawakita D, Beppu S, Torii J, Murakami S.
    • Journal Title

      Japan Journal of Clinical Oncology

      Volume: 47(11) Issue: 11 Pages: 1031-1037

    • DOI

      10.1093/jjco/hyx115

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of oral hygiene on head and neck cancer risk in a Chinese population.2017

    • Author(s)
      Kawakita D, Lee YA, Li Q, Chen Y, Chen CJ, Hsu WL, Lou PJ, Zhu C, Pan J, Shen H, Ma H, Cai L, He B, Wang Y, Zhou X, Ji Q, Zhou B, Wu W, Ma J, Boffetta P, Zhang ZF, Dai M, Hashibe M.
    • Journal Title

      Head and Neck

      Volume: 39(12) Issue: 12 Pages: 2549-2557

    • DOI

      10.1002/hed.24929

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biomarker immunoprofile in salivary duct carcinomas: clinicopathological and prognostic implications with evaluation of the revised classification2017

    • Author(s)
      Takase Soichiro、Kano Satoshi、Tada Yuichiro、Sato Yukiko、et al.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 35 Pages: 59023-59035

    • DOI

      10.18632/oncotarget.19812

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dermopathy associated with cetuximab and panitumumab: investigation of the usefulness of moisturizers in its management.2017

    • Author(s)
      Watanabe S, Nakamura M, Takahashi H, Hara M, Ijichi K, Kawakita D, Morita A.
    • Journal Title

      Clinical, Cosmetic and Investigational Dermatology.

      Volume: 11;10 Pages: 353-361

    • DOI

      10.2147/ccid.s140796

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alcohol and head and neck cancer.2017

    • Author(s)
      Kawakita D, Matsuo K.
    • Journal Title

      Cancer and Metastasis Reviews

      Volume: 36(3) Issue: 3 Pages: 425-434

    • DOI

      10.1007/s10555-017-9690-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.2017

    • Author(s)
      Kawakita D, Lee YA, Turati F, Parpinel M, Decarli A, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Garavello W, Schantz S, Yu GP, Boffetta P, Chuang SC, Hashibe M, Ferraroni M, La Vecchia C, Edefonti V.
    • Journal Title

      International Journal of Cancer

      Volume: 141(9) Issue: 9 Pages: 1811-1821

    • DOI

      10.1002/ijc.30886

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Global trends in nasopharyngeal cancer mortality since 1970 and predictions for 2020: Focus on low-risk areas.2017

    • Author(s)
      Carioli G, Negri E, Kawakita D, Garavello W, La Vecchia C, Malvezzi M.
    • Journal Title

      International of Cancer

      Volume: 140(10) Issue: 10 Pages: 2256-2264

    • DOI

      10.1002/ijc.30660

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 下咽頭癌手術におけるORBEYEの使用経験-粘膜切除から遊離再建まで-2020

    • Author(s)
      的場 拓磨、高野 学、小栗 恵介、岩城 翔、佐藤 秀吉、鳥山 和宏、川北 大介
    • Organizer
      第30回日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 頸部回旋により外頸動脈損傷を来した皮膚筋炎合併異所性頸長筋石灰化例2020

    • Author(s)
      纐纈 祐弥、斎藤 明子、今泉 冴恵、岩城 翔、小栗 恵介、高野 学、的場 拓磨、川北 大介
    • Organizer
      第30回日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 降下性壊死性縦隔炎22症例の臨床的検討2020

    • Author(s)
      川北 大介、川口 加那、欄 真一郎、小澤 泰次郎、原田 生功磨、三矢 昭治、中村 善久、森部 一穂、岩﨑 真一
    • Organizer
      第30回日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 手術治療を行った耳下腺癌72症例の臨床的検討2020

    • Author(s)
      今泉 冴恵、的場 拓磨、高野 学、小栗 恵介、岩城 翔、川北 大介
    • Organizer
      第30回日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮膚悪性黒色腫頭頸部転移に対する治療経験2020

    • Author(s)
      岩城 翔、的場 拓磨、高野 学、今泉 冴恵、小栗 恵介、川北 大介
    • Organizer
      第30回日本頭頸部外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Trastuzumab plus docetaxel in patients with advanced HER2 positive salivary duct carcinoma: Exploratory biomarker analyses2019

    • Author(s)
      Takahashi H, Kawakita D, Fushimi C, Nagao T, Hirai H, Saigusa N, Masubuchi T, Matsuki T, Okada T, Baba D, Miura K, Saotome T, Tada Y
    • Organizer
      ESMO annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined androgen blockade in patients with advanced androgen receptor positive salivary gland carcinoma: Exploratory biomarker analyses2019

    • Author(s)
      Fushimi C, Kawakita D, Takahashi H, Nagao T, Hirai H, Saigusa N, Masubuchi T, Matsuki T, Okada T, Baba D, Miura K, Saotome T, Tada Y
    • Organizer
      ESMO annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nivolumabを投与した再発転移頭頸部扁平上皮癌88例における血液学的予後マーカーの検討 多施設共同研究2019

    • Author(s)
      松木 崇, 山下 拓, 岡本 伊作, 佐藤 宏樹, 塚原 清彰, 近藤 貴仁, 三浦 弘規, 多田 雄一郎, 伏見 千宙, 岡田 拓朗, 川北 大介, 澤部 倫, 小村 豪
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス口腔癌における腫瘍溶解ウイルスHF10とオキサリプラチンの抗腫瘍効果2019

    • Author(s)
      高野 学, 江崎 伸一, 岩城 翔, 小栗 恵介, 的場 拓磨, 川北 大介, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 単純ヘルペスウイルスHF10による転移性腫瘍への抗腫瘍効果2019

    • Author(s)
      江崎 伸一, 五島 典, 高野 学, 波多野 芳美, 川北 大介, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 部位別にみた唾液腺腺様嚢胞癌の臨床病理学的特徴:多施設共同研究による200症例の検討2019

    • Author(s)
      上田 佳緒璃, 川北 大介, 村瀬 貴幸, 稲垣 宏
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗PD-1抗体投与後に心外膜炎を来した1例2019

    • Author(s)
      小栗 恵介, 川北 大介, 村嶋 明大, 的場 拓磨, 岩城 翔, 田中 伸和, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] S-1療法との関連が疑われたニボルマブ関連大腸炎の2例2019

    • Author(s)
      岩城 翔, 川北 大介, 小栗 恵介, 村嶋 明大, 的場 拓磨, 高野 学, 田中 伸和, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] レンバチニブ投与中に喉頭形成術を施行した甲状腺癌例2019

    • Author(s)
      的場 拓磨, 川北 大介, 讃岐 徹治, 高野 学, 小栗 恵介, 村嶋 明大, 岩城 翔, 田中 伸和, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 甲状腺未分化癌に対してレンバチニブ療法を施行した3症例2019

    • Author(s)
      川北 大介, 小栗 恵介, 村嶋 明大, 的場 拓磨, 高野 学, 岩城 翔, 田中 伸和, 村上 信五
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 外耳道難治性潰瘍に対するPerifascial Areolar Tissue(PAT)移植の経験2019

    • Author(s)
      佐藤 秀吉, 恒川 幸代, 小山 千里, 鳥山 和宏, 伊地知 圭, 川北 大介
    • Organizer
      第62回日本形成外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院での遊離空腸移植術における術後合併症の検討2019

    • Author(s)
      佐藤 秀吉, 恒川 幸代, 鳥山 和宏, 川北 大介
    • Organizer
      第62回日本形成外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 名古屋市立大学関連施設における降下性壊死性縦隔炎症例の検討2019

    • Author(s)
      川口 加那, 川北 大介, 村上 信五
    • Organizer
      第7回日本耳鼻咽喉科感染症・エアロゾル学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嚥下改善手術を要した頸部壊死性筋膜炎例2019

    • Author(s)
      豊田 貴一, 川北 大介, 高野 学, 中井 一之, 鈴木 元彦, 村上 信五
    • Organizer
      第7回日本耳鼻咽喉科感染症・エアロゾル学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 唾液腺導管癌ではadipophilinの発現が予後不良因子となりうる2019

    • Author(s)
      平井 秀明, 多田 雄一郎, 川北 大介, 中黒 匡人, 三枝 奈津季, 長尾 俊孝
    • Organizer
      第108回日本病理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 唾液腺導管癌における脂質関連蛋白発現の臨床病理学的意義2019

    • Author(s)
      平井 秀明, 多田 雄一郎, 中黒 匡人, 川北 大介、等
    • Organizer
      第64回日本唾液腺学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The impact of Lenvatinib on clinical outcome in patients with locally advanced or metastatic thyroid carcinoma.2019

    • Author(s)
      Kawakita D, Iwaki S, Oguri K, Murashima A, Matoba T, Takano G, Murakami S.
    • Organizer
      6th Asian Society of Head and Neck Oncology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Carboplatin plus Paclitaxel in patients with recurrent/metastatic head and neck carcinoma who were unsuitable for Cisplatin-based chemotherapy.2019

    • Author(s)
      Iwaki S, Kawakita D, Oguri K, Murashima A, Matoba T, Takano G, Murakami S.
    • Organizer
      6th Asian Society of Head and Neck Oncology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel approach for unresectable salivary duct carcinoma: Targeting HER2 and androgen receptor.2018

    • Author(s)
      Kawakita D, Tada Y, Fushimi C, Takahashi H, Masubuchi T, Miura K, Kano S, Tsukahara K, Ozawa H, Okami K, Sato Y, Shimizu A, Imanishi Y, Hanazawa T, Ando M, Hirai H, Nagao T.
    • Organizer
      2018 American Society of Clinical Oncology Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 導入化学療法を施行した上咽頭癌の治療成績2018

    • Author(s)
      川北大介、鈴木海斗、柘植博之、的場拓磨、高野学、村嶋明大、村上信五
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 唾液腺癌モデルマウスにおける腫瘍溶解ウイルスHF10とTS-1の併用療法の効果2018

    • Author(s)
      江崎伸一、五島典、高野学、波多野芳美、伊地知圭、川北大介、村上信五
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウス扁平上皮癌における腫瘍溶解ウイルスHF10とIL2搭載アンプリコンの抗腫瘍効果2018

    • Author(s)
      高野学、江崎伸一、五島典、波多野芳美、川北大介、伊地知圭、村上信五
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 乳頭癌と髄様癌を同時に認めた甲状腺衝突癌2018

    • Author(s)
      的場拓磨、川北大介、高野学、鈴木海斗、村嶋明大、柘植博之、村上信五
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 薬剤耐性頭頸部扁平上皮癌におけるシグナル伝達経路の変化の検討2018

    • Author(s)
      波多野芳美、江崎伸一、五島典、高野学、伊地知圭、川北大介、足立誠、小川徹也、村上信五
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 唾液腺原発腺様嚢胞癌におけるEGFRタンパク高発現とその臨床病理学的意義2018

    • Author(s)
      村瀬貴幸、斎田昴佑、川北大介、草深公秀、長尾徹、花井信広、丹生健一、稲垣宏
    • Organizer
      第42回日本頭頸部癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胸部食道癌甲状腺内転移の一例2018

    • Author(s)
      川北大介、柘植博之、的場拓磨、高野学、鳥居淳一、村上信五
    • Organizer
      第28回日本頭頸部外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Lenvatinib therapy for advanced or metastatic thyroid cancer in Nagoya City University Hospital2017

    • Author(s)
      Kawakita D, Beppu S, Ijichi K, Murakami S.
    • Organizer
      2nd Congress of Asia-Pacific Society of Thyroid Surgery
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metastasis of thoracic esophageal carcinoma to the thyroid: a case report2017

    • Author(s)
      Tsuge H, Kawakita D, Ijichi K, Murakami S.
    • Organizer
      2nd Congress of Asia-Pacific Society of Thyroid Surgery
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 名古屋市立大学におけるTPFレジメンを用いた導入化学療法2017

    • Author(s)
      鳥居淳一、伊地知圭、蒲谷嘉代子、川北大介、別府慎太郎、的場拓磨、村上信五
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭頸部癌における飲酒の治療法における影響の違い2017

    • Author(s)
      澤部倫、川北大介、伊地知圭、伊藤秀美、長谷川泰久、松尾恵太郎、村上信五
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌における根治治療後無再発期間の再発後予後への影響2017

    • Author(s)
      川北大介、澤部倫、伊藤秀美、村上信五、長谷川泰久、松尾恵太郎
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] IL2搭載HSVアンプリコンベクターによる抗腫瘍効果の検討2017

    • Author(s)
      江崎伸一、五島典、鈴木亮太、波多野芳美、澤部倫、別府慎太郎、川北大介、伊地知圭、村上信五
    • Organizer
      第41回日本頭頸部癌学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 甲状腺悪性腫瘍手術における術中神経モニタリングとエナジーデバイスの活用-術後合併症リスク軽減を目指して-2017

    • Author(s)
      川北大介、鈴木海斗、高木亮、柘植博之、石川元基、伊地知圭、村上信五
    • Organizer
      第19回耳鼻咽喉科手術支援システム・ナビ研究会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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