Mechanisms to regulate neuronal migration using scaffolds after neonatal brain injury to promote neural regeneration
Project/Area Number |
17K18007
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Embryonic/Neonatal medicine
Neurophysiology / General neuroscience
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Research Institution | Nagoya City University |
Principal Investigator |
Jinnou Hideo 名古屋市立大学, 医薬学総合研究院(医学), 助教 (40788387)
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Project Period (FY) |
2017-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 新生児 / 脳傷害 / 神経幹細胞 / ニューロン / 再生 / 神経再生 / 脳室下帯 / ニューロン再生 / 放射状グリア / 足場 / N-cadherin / 新生児医学 / 再生医学 / 神経科学 |
Outline of Final Research Achievements |
I used neonatal mouse brain injury model, and found that radial glial fibers persist after neonatal brain injury to support the migration of ventricular-subventricular zone derived neuroblasts toward the injured area. new neurons and radial glial fibers form N-cadherin-dependent homophilic adhesion to promote fiber-guided neuronal migration. Furthermore, N-cadherin-containing sponge promotes neuronal migration and maturation, and functional recovery after neonatal brain injury.
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Academic Significance and Societal Importance of the Research Achievements |
放射状グリアの生後の機能はこれまで不明であったが、本研究により新生児期におけるその新しい役割を見出すことができたことは学術的意義が大きい。 また、新生児脳が高いニューロン再生能を持つ詳細な制御メカニズムを世界で初めて発見し、その方法を応用することによって再生の促進に成功した。このことから、新生児脳傷害におけるニューロン再生の臨床応用へつながる大きな前進となった意味で社会的意義が高い。
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Report
(7 results)
Research Products
(19 results)
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[Journal Article] Radial glial fibers support neuronal migration and regeneration after neonatal brain injury.2018
Author(s)
Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Perez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, Garcia-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.
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Journal Title
Cell Stem Cell
Volume: 22
Issue: 1
Pages: 128-137
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury2018
Author(s)
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto
Organizer
第60回日本小児神経学会
Related Report
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[Presentation] Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury.2018
Author(s)
Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.
Organizer
NCU Young Global Investigator Forum 2018
Related Report
Int'l Joint Research
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