Analysis of long non-coding RNAs and associated complex in ovarian cancer
| Project/Area Number |
17K18061
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
Tumor biology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
Mitobe Yuichi 埼玉医科大学, 医学部, 研究員 (50783255)
|
|---|
| Project Period (FY) |
2017-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 長鎖非コードRNA / 卵巣がん / がん特異的長鎖非コードRNA / 子宮内膜がん |
|---|
| Outline of Final Research Achievements |
Ovarian cancer is the most poor prognostic cancer in women. Recent advances in sequencing technology have revealed that long non-coding RNAs (lncRNAs) are substantially associated with biological phenomena including cancer development and progression. We identified lncRNAs that are highly expressed in ovarian cancer clinical samples. Knockdown using siRNA against this lncRNA impaired cell growth of ovarian cancer cells in vitro and in vivo. These results suggest that this lncRNA could be novel diagnostic and therapeutic target for ovarian cancer.
|
| Academic Significance and Societal Importance of the Research Achievements |
卵巣がんで多く発現しており、また未だ報告されていない長鎖非コードRNAを複数同定した。これら新しい長鎖非コードRNAは正常の卵巣組織ではほとんど発現が確認できないことから、婦人科腫瘍のなかでも死亡率が高いとされる卵巣がんの新規診断、もしくは治療のターゲットになりうることが示唆され、社会的な意義があると考える。さらにこの長鎖非コードRNAが卵巣がんの細胞増殖に強く関わっていることを、細胞株、また生体(マウス)を用いた実験によっても明らかにしており、学術的にも意義深い。
|
Report
(3 results)
Research Products
(6 results)
