Integrated understanding of evolution and development of human brain structures by parcellation of the primate brain MRIs

• Project/Area Number: 17K18097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical anthropology; Nerve anatomy/Neuropathology
• Research Institution: National Institutes for Quantum and Radiological Science and Technology (2019); Keio University (2017-2018)
• Principal Investigator: Sakai Tomoko 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常) (30640099)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: オープンサイエンス / 計算解剖学 / 比較神経科学 / 脳進化 / 脳発達 / 霊長類 / DTI / MRI / MRI画像解析 / 計算解剖学的手法 / 比較脳解剖イメージング / コモンマーモセット / チンパンジー

Outline of Final Research Achievements

This research had the following three results. (1) We have developed and released a primate brain image repository by scanning high-resolution structure MRIs images and DTs from 19 nonhuman primate species. (2) We have performed a cross-species comparison for the developmental patterns of the corpus callosum, which is the most nerve bundle that connects the cerebral hemispheres, among marmosets, chimpanzees, and humans. We found the homology and heterogeneity in the development of the corpus callosum regions related to allo-mothering and sociality. (3) Applying a cutting edge image registration algorithm, we have developed a computational anatomical technology that enables to quantity comprehensively the evolutionary changes of the brain anatomy. These results enable us to elucidate the homology and heterogeneity of the brain system among primates and the evolutionary origin of the human-specific brain system.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ヒト脳で開発された最先端の画像変形アルゴリズムを霊長類脳にも展開することで、脳構造の進化的変化を高精度に検出する計算技術を開発した。さらに、9.4テスラ高磁場MRIにより、20種の霊長類脳の脳構造画像と拡散強調画像のデータベースを開発し、広く供した。このように計算解剖学で醸造された最先端技術の射程を、人類進化学や脳科学にまで拡大することは、学際的見地からみても新規であり、ヒトの認知機能の進化基盤を推測するうえでも重要であることから、非常に特色のある研究となった。さらに、霊長類モデルを用いた精神・神経疾患の前臨床研究への応用にも貢献できることから、大きな波及効果をもたらすと考える。

Research Products

• [Int'l Joint Research] Radiology and Radiological Science/JHMI(米国)
• [Int'l Joint Research] The National Chimpanzee Brain Resource(米国)
• [Int'l Joint Research] Faculty of Science/Complex Traits Genetics, CNCR/VU Amsterdam(オランダ)
• [Int'l Joint Research] JNCA/University of Strasbourg(フランス)
• [Int'l Joint Research] Johns Hopkins University(米国)
• [Int'l Joint Research] Department of Radiology/Johns Hopkins University/School of Medicine(米国)
• [Journal Article] Accelerating the Evolution of Nonhuman Primate Neuroimaging (2020)
  • Author(s): Milham Michael、et al
  • Journal Title: Neuron Volume: 105 Issue: 4 Pages: 600-603
  • DOI: 10.1016/j.neuron.2019.12.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 霊長類比較脳MRI研究のためのJMC霊長類脳画像リポジトリ：精神・神経疾患の進化的起源の解明に向けて (2019)
  • Author(s): 酒井 朋子 , 畑純一、太田裕貴、新宅勇太、木村直人、森進、岡野ジェイムス洋尚、濱田穣、岡野栄之、 大石健一
  • Journal Title: 第47回日本磁気共鳴医学学会大会講演抄録集 Volume: 39 Pages: 223-223
• [Journal Article] The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species. (2018)
  • Author(s): Sakai T, Hata J, Ohta H, Shintaku Y, Kimura N, Ogawa Y, Sogabe K, Mori , Okano HJ, Hamada Y, Shibata S, Okano H, Oishi K.
  • Journal Title: Primates. Volume: 59(6) Issue: 6 Pages: 553-570
  • DOI: 10.1007/s10329-018-0694-3
  • NAID: 120006954914
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Developmental trajectory of the corpus callosum from infancy to the juvenile stage: Comparative MRI between chimpanzees and humans (2017)
  • Author(s): Sakai Tomoko、Mikami Akichika、Suzuki Juri、Miyabe-Nishiwaki Takako、Matsui Mie、Tomonaga Masaki、Hamada Yuzuru、Matsuzawa Tetsuro、Okano Hideyuki、Oishi Kenichi
  • Journal Title: PLOS ONE Volume: 12 Issue: 6 Pages: 1-34
  • DOI: 10.1371/journal.pone.0179624
  • NAID: 120006325120
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elucidation of developmental patterns of marmoset corpus callosum through a comparative MRI in marmosets, chimpanzees, and humans (2017)
  • Author(s): Tomoko Sakai, Yuji Komaki, Junichi Hata, Junko Okahara, Norio Okahara, Takashi Inoue, Akichika Mikami, Mie Matsui, Kenichi Oishi, Erika Sasaki, and Hideyuki Okano
  • Journal Title: Neuroscience Research Volume: 印刷中 Pages: 25-34
  • DOI: 10.1016/j.neures.2017.04.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 非ヒト霊長類の脳イメージング研究の発展・加速；The PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium (2020)
  • Author(s): 酒井朋子、南本敬史、平林敏行
  • Organizer: 第９回日本マーモセット研究会大会
  • Invited
• [Presentation] Mapping the Evolution and Development of the Primate Brain by Various Neuroimaging Techniques (2020)
  • Author(s): Tomoko Sakai
  • Organizer: 日本発生生物学会第53回大会
  • Invited
• [Presentation] Comparison of various primates specimen brain structure using MRI image (2020)
  • Author(s): Kazumi Sogabe, Junichi Hata, Tomoko Sakai, Yuta Shintaku, Hiroki Ohta, Hideyuki Okano, Hirotaka James Okano
  • Organizer: The 43st Annual Meeting of the Japan Neuroscience Society
• [Presentation] 霊長類比較脳MRI研究のためのJMC霊長類脳画像リポジトリ：精神・神経疾患の進化的起源の解明に向けて (2019)
  • Author(s): 酒井 朋子 , 畑純一、太田裕貴、新宅勇太、木村直人、森進、岡野ジェイムス洋尚、濱田穣、岡野栄之、 大石健一
  • Organizer: 第47回日本磁気共鳴医学学会大会
• [Presentation] 非ヒト霊長類の脳標本を使用した白質異方性拡散の拡散強調MRイメージングの特性 (2019)
  • Author(s): 曽我部和美, 畑純一, 酒井朋子, 新宅勇太, 太田裕貴, 岡野ジェイムス洋尚
  • Organizer: 第47回日本放射線技術学会秋季学術大会
• [Presentation] Mapping the Evolution and Development of the Primate Brain by Neuroimaging (2019)
  • Author(s): Tomoko Sakai
  • Organizer: Department of Experimental Psychology - Cognitive & Behavioural Neuroscience Seminar series (BEACON), Oxford University
  • Int'l Joint Research / Invited
• [Presentation] 最先端の計算解剖学的手法による比較霊長類脳イメージング研究 (2019)
  • Author(s): 酒井朋子
  • Organizer: 京都大学脳機能統合センター セミナー
  • Invited
• [Presentation] 最先端の計算解剖学的手法による比較霊長類脳イメージング研究の確立 (2019)
  • Author(s): 酒井朋子、畑純一、太田裕貴、新宅勇太、木村直人、岡野ジェイムス洋尚、濱田穣、岡野栄之、森進、大石健一
  • Organizer: 第8回日本マーモセット研究会大会
• [Presentation] 最新のコンピュターサイエンスがもたらす霊長類脳画像データーベース：サルにもヒトにもやさしい『オープンサイエンス』を目指して (2019)
  • Author(s): 酒井朋子、畑純一、太田裕貴、新宅勇太、木村直人、岡野ジェイムス洋尚、濱田穣、岡野栄之、森進、大石健一
  • Organizer: 第63回プリマーテス研究会
• [Presentation] The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species (2018)
  • Author(s): Sakai, T., Hata, J., Ohta, H., Shintaku, Y., Kimura, N., Ogawa, Y., Sogabe, K., Mori, S., Okano, H.J., Hamada, Y., Shibata, S., Okano, H., and Oishi, K.
  • Organizer: Annual Meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species (2018)
  • Author(s): Sakai, T., Hata, J., Ohta, H., Shintaku, Y., Kimura, N., Sogabe, K., Mori, S., Okano, H.J., Hamada, Y., Shibata, S., Okano, H., and Oishi, K
  • Organizer: International Symposium Towards Understandin “INDIVIDUALITY”
  • Int'l Joint Research
• [Presentation] The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species (2018)
  • Author(s): Sakai, T., Hata, J., Ohta, H., Shintaku, Y., Kimura, N., Ogawa, Y., Sogabe, K., Mori, S., Okano, H.J., Hamada, Y., Okano, H., and Oishi, K
  • Organizer: The 41st Annual Meeting of the Japan Neuroscience Society
• [Presentation] Development and evolution of human brain: insights from comparative anatomical MRI between chimpanzees and humans (2017)
  • Author(s): Tomoko Sakai
  • Organizer: The LANA Conference,
  • Int'l Joint Research / Invited
• [Book] 心の進化を語ろうー比較認知科学からの人間探求 (2019)
  • Author(s): 松沢 哲郎 編
  • Total Pages: 265
  • Publisher: 株式会社 岩波書店
  • ISBN: 9784000063364
• [Remarks] JMC Centre Primates Brain Imaging Repository
  • URL: http://www.j-monkey.jp/BIR/index_e.html
• [Remarks] Laboratory of Brain Anatomical MRI, JHM（共同研究先）
  • URL: http://lbam.med.jhmi.edu/
• [Remarks] The National Chimpanzee Brain Resource（共同研究先）
  • URL: https://www.chimpanzeebrain.org
• [Remarks] The dutch connectome lab, VU Amsterdam（共同研究先）
  • URL: http://www.dutchconnectomelab.nl/index.php#home
• [Remarks] LNCA, University of Strasbourg（共同研究先）
  • URL: https://lnca.fr/23.html
• [Remarks] Laboratory of Brain Anatomical MRI (JHMI)
  • URL: http://lbam.med.jhmi.edu/
• [Remarks] Laboratory of Brain Anatomical MRI
  • URL: http://lbam.med.jhmi.edu/