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Fundamental chronic pain study by the investigation of the relationship between aging and oxidative stress

Research Project

Project/Area Number 17K18111
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Pain science
Research InstitutionShowa University

Principal Investigator

Sato Hitoshi  昭和大学, 歯学部, 兼任講師 (00594954)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsTRPV1 / 活性酸素種 / 三叉神経脊髄路核 / 三叉神経節 / ROS / 侵害受容性疼痛 / 神経障害性疼痛 / c-Fos / ATF3 / 慢性疼痛 / 加齢変化 / 酸化損傷
Outline of Final Research Achievements

We prepared a cell line that stably expresses EGFP-TRPV1 at various levels. This cell line is assuming that the expression level of transient receptor potential vanilloid 1 (TRPV1), which is involved in the reception of noxious stimuli in chronic pain diseases, is elevated on the cell membrane of sensory nerves.
It was found that the TRPV1-highly expressing cell line produces active oxygen by agonist stimulation.
In addition, when a pain stimulus is applied to the trigeminal nerve innervation area, transcription factors that rapidly respond to various stresses and c-Fos that shows neuronal excitability are expressed in the trigeminal ganglion where many cell bodies are present.

Academic Significance and Societal Importance of the Research Achievements

活性酸素種は発現上昇したTRPV1のアゴニスト刺激により感覚神経から過剰に産生され、各組織の加齢に伴う抗酸化作用の低下により、周囲神経組織を障害することが予想される。超高齢化社会を迎えた我が国において高齢者の慢性疼痛への対応は医療経済の面からも急務であり、その病態機序とROSとの関係性が明らかとなったことにより、抗酸化作用を持つ薬剤や化合物の鎮痛効果について新たな知見が加えられた。これらの薬剤や化合物は生体安全性の高いものが多く,本研究結果は慢性疼痛疾患をかかえた高齢者にも安全に使用可能な薬物治療戦略確立への基盤となる.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Experimental Study on Involvement of the Central Nervous System in Inferior Alveolar Nerve Damage-Associated Hyperalgesia of the Mental Region2018

    • Author(s)
      Kiyomoto Masaaki、Shirota Tatsuo、Moriya Takashi、Sato Hitoshi、Nakamura Shiro、Inoue Tomio
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 76 Issue: 10 Pages: 2089.e1-2089.e8

    • DOI

      10.1016/j.joms.2018.06.021

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 下歯槽神経損傷後に生じる知覚異常と中枢神経組織の経日的変化2019

    • Author(s)
      佐藤 仁,稲田大佳暢,守谷 崇,代田達夫
    • Organizer
      第64回公益社団法人 日本口腔外科学会総会・学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 顎関節症の痛みの慢性化-中枢性感作を生じたら?-2019

    • Author(s)
      佐藤 仁
    • Organizer
      第32回一般社団法人日本顎関節学会総会・学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pathophysiological overlaps between temporomandibular disorders and tension-type headache2017

    • Author(s)
      Hitoshi Sato
    • Organizer
      BIT' 8th World Congress of NeuroTalk
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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