| Project/Area Number |
17K18209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
Conservative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | Qx-314 / Capsaicin / Endodontic pain / Trigeminal nerve / c-Fos / TRPV1 / QX314 / Local Anaesthetic / QX-CAP / Postoperative Pain |
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| Outline of Final Research Achievements |
We have investigated the possibility of using the combination of a permanently charged sodium channel blocker (QX-314) and a TRPV1 agonist (capsaicin; QX-CAP) in reducing postoperative pain after endodontic treatment. We have made an animal model to mimic endodontic treatment procedure. The dental pulp of the rat`s lower central incisor was exposed using dental drill and stimulated with an endodontic file to mimic the endodontic treatment procedure. A neuronal marker, c-Fos, expression increased in the trigeminal subnucleus caudalis (Vc) following the endodontic procedure compared to that of sham and naive rats, indicating increase of neuronal activity in the Vc due to the endodontic procedure. QX-CAP injection near the mandibular and mental nerve areas reduced the number of c-Fos expressing neurons in the Vc in rats with endodontic procedure, indicating reduction of endodontic procedure-induced neuronal activation by the QX-CAP injection.
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| Academic Significance and Societal Importance of the Research Achievements |
Anaesthetizing the nerves that supply the dental pulp of a tooth using the commbination of a permanently charged sodium channel blocker (QX-314) and a TRPV1 agonist (capsaicin; QX-CAP) prior to endodontioc procedure may reduce the pain during treatment of the dental pulp like root canal treatment.
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