The role of circulating MicroRNAs in Graves' Disease
| Project/Area Number |
17K18220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
Laboratory medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 甲状腺 / エクソソーム / miRNA / バセドウ病 / microRNA / 自己免疫甲状腺疾患 / 自己免疫疾患 |
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| Outline of Final Research Achievements |
Understanding the roles of circulating microRNAs (miRNAs) can provide important information regarding disease pathogenesis and a patient's clinical condition.This study revealed that different signature of circulating miRNAs are associated with intractable GD. Moreover, circulating miRNAs of patients with intractable GD may activate immune cells, which may play an important role in GD pathogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により自己免疫性甲状腺疾患、特にバセドウ病において変動する血中microRNAを明らかにした。これらの血中microRNAは甲状腺疾患の病態に関与することが示唆された。
これら成果は、これまで不明であった自己免疫性甲状腺疾患の病態解明につながるものである。さらなる将来的には治療や診断法の開発につながることが期待される。
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Prediction of Insulin Secretion Ability With Microcirculation Evaluated by Contrast-enhanced Ultrasonography in Pancreas Transplantation.2018
Author(s)
Aida N, Kenmochi T, Ito T, Nishikawa T, Hiratsuka I, Shibata M, Suzuki A, Hasegawa M, Kawai A, Kusaka M, Hoshinaga K, Matsubara H.
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Journal Title
Pancreas.
Volume: 47
Issue: 5
Pages: 617-624
DOI
Related Report
Peer Reviewed
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