Effects of food for specified health uses on central obesity mediated by thermogenic hormone
Project/Area Number |
17K18244
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
Applied health science
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Research Institution | Kyoto Prefectural University (2018-2019) Ryukoku University (2017) |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | FGF21 / 脂肪肝 / 内臓脂肪蓄積 / 隠れ肥満 / 大豆たんぱく質 / 大豆タンパク質 / 熱産生ホルモン / 内臓脂肪 / エネルギー消費量 / 熱産生 / 肝内脂肪 / 保健機能食品 |
Outline of Final Research Achievements |
This study examined the effects of soy protein intake on fibroblast growth factor 21 (FGF21) resistant-state and visceral fat mass.Our animal study showed that soy protein intake improved FGF21 resistance, thereby preventing visceral fat accumulation. In addition, a human dietary intervention study revealed that change in serum FGF21 level was associated with brown adipose tissue activity in soy protein-supplemented subjects.These results suggested that dietary soy protein intake has preventive effects on visceral fat accumulation and onset of metabolic diseases such as type 2 diabetes mellitus and cardiovascular diseases.
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Academic Significance and Societal Importance of the Research Achievements |
体重が適正であっても内臓脂肪が過剰に蓄積している隠れ肥満が、糖尿病や循環器疾患の原因となることが知られている。本研究は、習慣的な大豆タンパク質摂取が、脂肪燃焼ホルモンFibroblast growth factor 21 (FGF21)の脂肪燃焼効果を高める効果について、動物実験およびヒトを対象とした食事介入試験により明らかとした。FGF21の機能性について着目したこれらの研究成果は、隠れ肥満の予防・改善に習慣的な大豆タンパク質の摂取が有効である可能性を示唆している。
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Report
(4 results)
Research Products
(3 results)