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Investigation on the mechanism of novel multi-functional dental restoration/ sealing material

Research Project

Project/Area Number 17K18247
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Conservative dentistry
Research InstitutionOsaka Dental University

Principal Investigator

Shinonaga Yukari  大阪歯科大学, 歯学部, 講師 (70531961)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsグラスアイオノマーセメント / ハイドロキシアパタイト / セルロースナノファイバー / 機械的強度 / フッ化物イオン溶出能 / 酸緩衝能 / フッ化物イオン溶出 / セルロース / 再石灰化 / 抗菌性
Outline of Final Research Achievements

Recently, dental caries treatment has been required enamel-remineralization and residual pulp. The most suitable material for these treatments is glass ionomer cement (GIC), however, its mechanical strength is very low. Therefore, this study evaluated the hydroxyapatite (HAp) -added GIC that was developed to improve the mechanical strength of GIC and the GIC that added cellulose that does not react with GIC, and elucidated the reaction mechanism of HAp-added GIC.
As the results, addition of HAp to GIC showed improvement in mechanical and functional properties, and addition of cellulose showed improvement in mechanical strength. It was suggested that HAp in GIC not only strengthens GIC itself, but also influences ion release property and improvement of acid buffering capacity.

Academic Significance and Societal Importance of the Research Achievements

本研究は,小窩裂溝填塞材料として,GICへのHApの添加の有効性を見出し,さらに,その機能の向上は,HApを添加することによりセメント内部が物理的・化学的に改質されたことによると推察したAICの反応メカニズムを歯とGICの接着メカニズムから解明した点,またその比較のためにGICに反応しないセルロースを添加した試料を作製して評価した点は学術的意義が大きい。
また,社会的意義として,GICへのHApの添加はその機械的強度のみならず,フッ化物イオン溶出能や酸緩衝能も向上させたことから,今後,齲蝕治療の従来の考え方である「Drill & Fill」から脱却し,再石灰化療法を実践できると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Mechanical and functional properties of a novel apatite-ionomer cement for prevention and remineralization of dental caries2019

    • Author(s)
      Rie Imataki, Yukari Shinonaga, Takako Nishimura, Yoko Abe, Kenji Arita
    • Journal Title

      Materials (Basel)

      Volume: 12

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Powdery Cellulose Nanofiber Addition on the Properties of Glass Ionomer Cement2019

    • Author(s)
      Nishimura Takako、Shinonaga Yukari、Nagaishi Chikoto、Imataki Rie、Takemura Michiko、Kagami Keiichi、Abe Yoko、Harada Kyoko、Arita Kenji
    • Journal Title

      Materials

      Volume: 12 Issue: 19 Pages: 3077-3077

    • DOI

      10.3390/ma12193077

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Multi-Functional Dental Cement for Enamel Remineralization and Anti-Cariogenic Bacteria Activity2018

    • Author(s)
      Shinonaga Y, Arita K, Imataki R, Takemura M, Nagaishi C, Kagami K, Nishimura T, Abe Y, Aoki S, Okumura S, Harada K
    • Journal Title

      International Journal of Oral and Dental Health

      Volume: 4 Issue: 2 Pages: 1-7

    • DOI

      10.23937/2469-5734/1510065

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規アパタイトアイオノマーセメントの齲蝕予防と再石灰化に対する機械的および機能的特性2019

    • Author(s)
      今瀧梨江,篠永ゆかり,西村貴子,阿部洋子,有田憲司
    • Organizer
      第564回大阪歯科学会例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新規アパタイトアイオノマーセメントの酸緩衝能について2019

    • Author(s)
      今瀧梨江,篠永ゆかり,竹村美智子,加々美恵一,永石千琴,青木 翔,奥野真江,西村貴子,阿部洋子,原田京子,有田憲司
    • Organizer
      第38回日本小児歯科学会近畿地方会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 粉体セルロースナノファイバー添加がグラスアイオノマーセメントの物性に及ぼす影響2019

    • Author(s)
      永石千琴,篠永ゆかり,今瀧梨江,竹村美智子,加々美恵一,青木翔,西村貴子,阿部洋子,原田京子,有田憲司
    • Organizer
      第57回日本小児歯科学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of hydroxyapatite incorporated in resin-modified glass-ionomer cement2019

    • Author(s)
      Michiko Takemura, Yukari Shinonaga, Yoko Abe, Kyoko Harada, Kenji Arita
    • Organizer
      1st Asia Association for Disability and Oral Health
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アパタイトアイオノマーセメント中のハイドロキシアパタイトが担う役割の解明2018

    • Author(s)
      今瀧梨江,篠永ゆかり,入江正郎,有田憲司
    • Organizer
      第71回日本歯科理工学会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 光硬化型グラスアイオノマーセメントへのハイドロキシアパタイト添加による各種イオン溶出能への影響に関する研究.2018

    • Author(s)
      竹村美智子,今瀧梨江,永石千琴,加々美恵一,篠永ゆかり,西村貴子,阿部洋子,有田憲司
    • Organizer
      第56回日本小児歯科学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of Advanced Multi-Functional Material for Remineralization of Caries Lesion2018

    • Author(s)
      Imataki R, Shinonaga Y, Nishimura T, Abe Y, Arita K
    • Organizer
      FDI 2018 World Dental Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] セルロースナノファイバーはグラスアイオノマーセメントの特性を強化する2018

    • Author(s)
      永石千琴,城山佳洋,今瀧梨江,竹村美智子,加々美恵一,青木翔,奥野真江,篠永ゆかり,西村貴子,阿部洋子,原田京子,有田憲司
    • Organizer
      第37回日本小児歯科学会近畿地方会大会および総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Development of Apatite-Ionomer Cement -Influence of Differences in Mixture Ratio of GIC-glass, Liquid and Hydroxyapatite2017

    • Author(s)
      Yukari Shinonaga, Rie Imataki, Takako Nishimura, Michiko Takemura, Chikoto Nagaishi, Keiichi Kagami, Sho Aoki, Yoko Abe, Kenji Arita
    • Organizer
      CED-IADR/NOF Oral Health Research Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] アパタイトアイオノマーセメントの開発研究―粉末と液の配合量の違いが及ぼす影響―2017

    • Author(s)
      篠永ゆかり,邱思瑜,邱秀慧,今瀧梨江,竹村美智子,西村貴子,阿部洋子,有田憲司
    • Organizer
      第55回日本小児歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] アパタイトアイオノマーセメントの開発研究-2種のHApと2種の結晶セルロースが及ぼす影響-2017

    • Author(s)
      今瀧梨江,邱思瑜,邱秀慧,篠永ゆかり,竹村美智子,阿部洋子,西村貴子,有田憲司
    • Organizer
      第55回日本小児歯科学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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