Elucidating the mechanism of tumor resolution in methotrexate-related lymphoproliferative disease
| Project/Area Number |
17K18335
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
Tumor diagnostics
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Dobashi Akito 公益財団法人がん研究会, がん研究所 分子標的病理プロジェクト, 研究員 (40772249)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | メトトレキサート関連リンパ増殖性疾患 / 関節リウマチ / リンパ腫 / 全エクソンシーケンス / 全ゲノムバイサルファイトシーケンス / メトトレキサート / リンパ増殖性疾患 |
|---|
| Outline of Final Research Achievements |
Methotrexate-associated lymphoid proliferative disease (MTX-LPD) occurs in patients receiving MTX. This disease may show spontaneous remission after stopping the MTX treatment. Therefore, we conducted a comprehensive genetic analysis of cases requiring chemotherapy and those in remission after stopping MTX treatment. The remission mechanism of MTX-LPD was determined by comparing the chemotherapy cases and remission cases. Our findings showed that, the genetic background of MTX-LPD, which required chemotherapy, was similar to that of general diffuse large B-cell lymphoma. However, the genetic background of the two types of diseases was found to be different.
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| Academic Significance and Societal Importance of the Research Achievements |
化学療法が必要であった症例とMTXの中止だけで寛解が得られた症例の遺伝子網羅的な解析による比較を行い、MTX-LPDの自然消退機序の解明を行った。その結果、化学療法が必要であった症例とMTXの中止だけで寛解が得られた症例の間で異なる遺伝子プロファイルがみられることがわかった。また、化学療法が必要であったMTX-LPDは、一般的なDLBCLと比較すると、同様の遺伝子背景も認められるが、一部に異なった遺伝子の変化があることが判明した。これらの違いを指標として用いることで、診断時にMTX中止のみとするか、化学療法を行うかを見積もることが可能となる可能性がある。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas2019
Author(s)
Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
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Journal Title
Leukemia
Volume: Epub ahead of print
Issue: 7
Pages: 1687-1699
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] TP53 and OSBPL10 alterations in diffuse large B-cell lymphoma: prognostic markers identified via exome analysis of cases with extreme prognosis.2018
Author(s)
Dobashi A, Togashi Y, Tanaka N, Yokoyama M, Tsuyama N, Baba S, Mori S, Hatake K, Yamaguchi T, Noda T, Takeuchi K.
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Journal Title
Oncotarget
Volume: 9
Issue: 28
Pages: 19555-19568
DOI
Related Report
Peer Reviewed / Open Access
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