Study on mechanisms maintaining homology of muscles in vertebrate evolution
| Project/Area Number |
17K18354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Stratigraphy/Paleontology
General anatomy (including histology/embryology)
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Tatsuya Hirasawa 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員 (60585793)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脊椎動物 / 相同性 / 進化 / 胚発生 / 前肢筋 / 腕神経叢 / 化石 / 骨格筋 / 発生 / 四肢筋 / 発生・分化 / 古生物学 / 比較解剖学 |
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| Outline of Final Research Achievements |
To understand the mechanism maintaining morphological homology of skeletal muscles in vertebrate evolution, I studied the developmental process of the relationship between skeletal muscles and spinal nerves, which is fairly conserved in evolution, during embryonic development, as well as investigated its evolvability. My embryonic experiments were suggestive of that, contrary to the initial expectation, the interaction with developing axons of spinal nerves is not essential for the individualization process of muscle primordia. I also published a review paper proposing a new research framework for this subject.
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| Academic Significance and Societal Importance of the Research Achievements |
脊椎動物進化の中で筋の相同性が保たれるしくみとして筋前駆細胞集団から個々の筋に分かれる過程に注目した先駆的な研究であり、その完全解明のための基礎となる。また、この解明を進めることで、脊椎動物の形態進化についてだけでなく、生物進化における制約や方向性について、あるいはどのようなときに新しい形態パターンが進化できるのかについての全般的理解につながっていくと期待される。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] 1.Anatomical integration of the sacral-hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods.2017
Author(s)
Matsubara Y., Hirasawa T., Egawa S., Hattori A., Suganuma T., Kohara Y., Nagai T., Tamura K., Kuratani S., Kuroiwa A., Suzuki T
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Journal Title
Nature Ecology and Evolution
Volume: １
Issue: 9
Pages: 1392-1399
DOI
Related Report
Peer Reviewed
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[Journal Article] Outflow tract septation and the aortic arch system in reptiles: lessons for understanding the mammalian heart2017
Author(s)
Poelmann RE, Gittenberger-de Groot AC, Biermans MWM, Dolfing AI, Jagessar A, van Hattum S, Hoogenboom A, Wisse LJ, Vicente-Steijn R, de Bakker MAG, Vonk FJ, Hirasawa T, Kuratani S, Richardson MK
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Journal Title
EvoDevo
Volume: 8
Issue: 1
Pages: 9-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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