| Project/Area Number |
17K18367
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
General physiology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
PARK YUNKYUNG 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (50568863)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | ITGβ3 / anxiety / network oscillation / synaptic plasticity / homeostasis / thorny excrescence / mossy fiber / circuit specificity / mossy fiber bouton / synaptoporin / CA3 pyramidal neurons / adult neurogenesis / integrin β3 / synaptic scaling |
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| Outline of Final Research Achievements |
Integrins are cell adhesion proteins that have been intensively invesitgated in the field of cancer or immune-related disease research. Yet, their subunit-specific function and presence in the bran remain largely unknown. In this study, integrin(ITG)β3-dependent cellular and network mechanisms underlying anxiety-like behavior have been explored in mature hippocampal circuit.In CA3, both pre and post ITGβ3 mediate the excitatory basal synaptic transmission between mossy fiber from dentate gyrus and thorny excrescence of pyramidal neurons which, in turn, modulates the frequency and power of network oscillation. Interestingly, its modulatory mechanism in mossy fiber is more crucial for maintaining the homeostasis or adaptation between older and newer granule cells in dentate gyrus during ongoing adult neurogenesis, requiring its presence throughout the critical periods of early development.
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| Academic Significance and Societal Importance of the Research Achievements |
This study reports the physiological roles of neuronally expressed ITGβ3 for mature hippocampal circuit in a cell-type specific manner for the first time. It will also help future studies in the field of stress, anxiety disorder, drug addiction and autism, in which ITGβ3 have been implicated.
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