Validity of Dietary Inflammatory Index (DII) assesed by food frequency questionnaire and the association between DII and colorectal cancer risk

• Project/Area Number: 17K18389
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine; Eating habits
• Research Institution: Azabu University (2019); National Cancer Center Japan (2017-2018)
• Principal Investigator: Kotemori Ayaka 麻布大学, 生命・環境科学部, 特任助教 (70701233)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 栄養疫学 / 炎症 / 妥当性 / 食事記録 / 食物摂取頻度調査 / バイオマーカー / 高感度CRP / インターロイキン-6 / がん / 食事

Outline of Final Research Achievements

Chronic inflammation status is involved in the development and proliferation of cancer cells. The Dietary Inflammatory Index (DII) is used internationally as a comprehensive index to measure impact of diet on inflammation status. There are no validation studies among DII score in Japan, therefore, we examined the association between DII scores and inflammatory biomarkers, and further examined the association between DII and colorectal cancer risk as a one of the inflammation related diseases. As a result of validation study using biomarkers, the validity was confirmed in men, but not in women. In addition, a positive association between DII score and colorectal cancer risk was observed in men in a prospective cohort study among 90,000 participants in Japan. However, no association was observed in Japanese women.

Academic Significance and Societal Importance of the Research Achievements

日本人を対象としたバイオマーカーを用いたDIIの妥当性研究は、本研究期間中に本研究の成果を含む2報が報告された。これらの結果を比較すると、男性・女性に分けたときの結果は研究間で結論が一致していなかった。したがって、日本人においてDIIを用いた食事評価を行うためにはさらなる検討が必要だと考えられた。

Research Products

• [Int'l Joint Research] University of South Carolina(米国)
• [Int'l Joint Research] University of South Carolina(米国)
• [Int'l Joint Research] University of South Carolina(米国)
• [Journal Article] JPHC FFQ Validation Study Group. Validating the dietary inflammatory index using inflammatory biomarkers in a Japanese population: A cross-sectional study of the JPHC-FFQ validation study. (2020)
  • Author(s): Kotemori A, Sawada N, Iwasaki M, Yamaji T, Shivappa N, Hebert JR, Ishihara J, Inoue M, Tsugane S
  • Journal Title: Nutrition. Volume: 69 Pages: 110569-110569
  • DOI: 10.1016/j.nut.2019.110569
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Association between dietary inflammatory index and high-sensitive C-reactive protein levels in cancer screening in Japanese (2018)
  • Author(s): Ayaka Kotemori
  • Organizer: European Congress of Epidemiology (EUROEPI 2018), Lyon, France.
  • Int'l Joint Research
• [Presentation] Validity of a food-frequency questionnaire for dietary inflammatory index: the JPHC FFQ Validation Study (2017)
  • Author(s): Ayaka Sunami (Kotermori), Junko Ishihara, Norie Sawada, Motoki Iwasaki, Nitin Shivappa, James R. Hebert, Manami Inoue, Shoichiro Tsugane
  • Organizer: 21th International Congress of Nutrition (ICN2017),
  • Int'l Joint Research
• [Remarks] 食事調査票から得られた食事由来の炎症修飾能の正確さについて
  • URL: https://epi.ncc.go.jp/jphc/outcome/8448.html