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Development of multivariable graph representation data analysis method and its application to clinical data

Research Project

Project/Area Number 17K18445
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Epidemiology and preventive medicine
Research InstitutionShizuoka Prefectural Hospital Organization (2019-2020)
Foundation for Biomedical Research and Innovation at Kobe (2018)
Osaka University (2017)

Principal Investigator

Nakatani Eiji  地方独立行政法人静岡県立病院機構静岡県立総合病院(救急診療部、循環器病診療部、がん診療部、臨床診療部, 統計解析室, 室長 (80627670)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords臨床経過 / グラフ表現図 / 構造化モデル / アンサンブル学習 / 集合解 / 樹木モデル / 平均因果効果 / 交互作用項検定 / 部分集団 / 層別 / アンサ ンブル学習 / ブートストラップ法
Outline of Final Research Achievements

After the onset of a disease, the disease progresses with a variety of symptoms. I conducted a study to draw a statistically accurate picture of the typical symptom changes in patients with such a disease using data. In the first half of the study, I listed the statistical problems for drawing such a diagram. In the second half of the study, I conducted individual statistical studies on these problems. Through this research, I published many papers in the field of medicine and gave four international conference presentations in the field of statistics.

Academic Significance and Societal Importance of the Research Achievements

この研究において進めた,疾患に罹った患者における代表的な症状の移り変わりを示す図を統計学に正確に描ければ,医療における治療やケア計画の立案に役立つし,疾患の特徴をより深く理解することができます.まだ研究は途中ではありますが,この研究のプロセスでわかった統計学や医療分野での問題点に対する研究の成果は,多くの論文公表と学会発表を行ったことで,医療統計学や疫学の分野での発展に寄与したと考えています.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 18 results,  Open Access: 10 results) Presentation (6 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Data Resource Profile of Shizuoka Kokuho Database (SKDB) Using Integrated Health- and Care-insurance Claims and Health Checkups: The Shizuoka Study2022

    • Author(s)
      Nakatani Eiji、Tabara Yasuharu、Sato Yoko、Tsuchiya Atsuko、Miyachi Yoshiki
    • Journal Title

      Journal of Epidemiology

      Volume: 32 Issue: 8 Pages: 391-400

    • DOI

      10.2188/jea.JE20200480

    • NAID

      130007977685

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2022-08-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A retrospective assessment of the safety and efficacy of laparoscopic radical hysterectomy in Japan during the early years following its introduction: a Japanese Gynecologic Oncology Group study (JGOG1081S)2021

    • Author(s)
      Kobayashi Eiji、Kanao Hiroyuki、Takekuma Munetaka、Nishio Shin、Kojima-Chiba Atsumi、Tozawa Akiko、Yamaguchi Satoshi、Takeshima Nobuhiro、Nakatani Eiji、Mikami Mikio
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 2 Pages: 417-428

    • DOI

      10.1007/s10147-020-01799-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late-onset development of psoriasis in Japan: a population-based cohort study2021

    • Author(s)
      Goto Haruka、Nakatani Eiji、Yagi Hiroaki、Moriki Mutsumi、Sano Yuko、Miyachi Yoshiki
    • Journal Title

      JAAD International

      Volume: 2 Pages: 51-61

    • DOI

      10.1016/j.jdin.2020.10.011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Factors for Pneumonia and Death in Adult Patients With Seasonal Influenza and Establishment of Prediction Scores: A Population-Based Study2021

    • Author(s)
      Miyashita Koichi、Nakatani Eiji、Hozumi Hironao、Sato Yoko、Miyachi Yoshiki、Suda Takafumi
    • Journal Title

      Open Forum Infectious Diseases

      Volume: 8 Issue: 3

    • DOI

      10.1093/ofid/ofab068

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plateau is a prognostic factor of lenalidomide therapy for previously treated multiple myeloma2021

    • Author(s)
      Takakuwa Teruhito、Ohta Kensuke、Nakatani Eiji、Ito Tomoki、Kaneko Hitomi、Fuchida Shin‐Ichi、Shimura Yuji、Yagi Hideo、Shibayama Hirohiko、Kanda Junya、Uchiyama Hitoji、Kosugi Satoru、Tanaka Hirokazu、Kawata Eri、Uoshima Nobuhiko、Ishikawa Jun、Shibano Masaru、Karasuno Takahiro、Shindo Maki、Shimizu Yoshifumi、等
    • Journal Title

      Hematological Oncology

      Volume: 未定 Issue: 3 Pages: 349-357

    • DOI

      10.1002/hon.2863

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy Comparison for a Schizophrenia and a Dysuria Drug Among East Asian Populations: A Retrospective Analysis Using Multi-regional Clinical Trial Data2021

    • Author(s)
      Sai Kimie、Nakatani Eiji、Iwama Yasuhiro、Hiraoka Shuichi、Tohkin Masahiro、Uyama Yoshiaki、Saito Yoshiro
    • Journal Title

      Therapeutic Innovation & Regulatory Science

      Volume: 55 Issue: 3 Pages: 523-538

    • DOI

      10.1007/s43441-020-00246-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)2021

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Murotani Kenta、Matsui Shigeyuki、Teramukai Satoshi、Sugai Tamotsu、Ajioka Yoichi、Maruo Hirotoshi、Kotaka Masahito、Tsujie Masaki、Munemoto Yoshinori、Yamaguchi Takashi、Kuroda Hisashi、Fukunaga Mutsumi、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      British Journal of Cancer

      Volume: 124 Issue: 6 Pages: 1088-1097

    • DOI

      10.1038/s41416-020-01222-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New predictive models for falls among inpatients using public ADL scale in Japan:?A retrospective observational study of 7,858 patients in acute care setting2020

    • Author(s)
      Tago Masaki、Katsuki Naoko E.、Oda Yoshimasa、Nakatani Eiji、Sugioka Takashi、Yamashita Shu-ichi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 7 Pages: e0236130-e0236130

    • DOI

      10.1371/journal.pone.0236130

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoglobulin free light chains as an inflammatory biomarker of heart failure with myocarditis2020

    • Author(s)
      Matsumori Akira、Shimada Toshio、Nakatani Eiji、Shimada Miho、Tracy Steven、Chapman Nora M.、Drayson Mark T.、Hartz Vernon L.、Mason Jay W.
    • Journal Title

      Clinical Immunology

      Volume: 217 Pages: 108455-108455

    • DOI

      10.1016/j.clim.2020.108455

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Size of the thoracic inlet predicts cervical anastomotic leak after retrosternal reconstruction after esophagectomy for esophageal cancer2020

    • Author(s)
      Sato Shinsuke、Nakatani Eiji、Higashizono Kazuya、Nagai Erina、Taki Yusuke、Nishida Masato、Watanabe Masaya、Oba Noriyuki
    • Journal Title

      Surgery

      Volume: 168 Issue: 3 Pages: 558-566

    • DOI

      10.1016/j.surg.2020.04.021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer2020

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Matsui Shigeyuki、Teramukai Satoshi、Murotani Kenta、Ajioka Yoichi、Shimazaki Hideyuki、Maeda Atsuyuki、Takuma Kunio、Yoshida Takefumi、Kambara Takeshi、Matsuda Keiji、Takagane Akinori、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      American Journal of Surgical Pathology

      Volume: 44 Issue: 12 Pages: 1685-1698

    • DOI

      10.1097/pas.0000000000001570

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial2019

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Matsuda Chu、Nakamoto Yoshihiko、Kotake Masanori、Kurachi Kiyotaka、Egawa Tomohisa、Yasumasa Keigo、Murata Kohei、Ikawa Osamu、Shinji Seiichi、Murotani Kenta、Matsui Shigeyuki、Teramukai Satoshi、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      Journal of Clinical Oncology

      Volume: 37 Issue: 22 Pages: 1886-1894

    • DOI

      10.1200/jco.18.02059

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of sodium-glucose cotransporter 2 inhibitor (dapagliflozin) on food intake and plasma fibroblast growth factor 21 levels in type 2 diabetes patients2019

    • Author(s)
      Kosugi Rieko、Nakatani Eiji、Okamoto Kensuke、Aoshima Saeko、Arai Hidekazu、Inoue Tatsuhide
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 8 Pages: 677-682

    • DOI

      10.1507/endocrj.EJ19-0013

    • NAID

      130007696451

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Allergen‐specific IgG4 over time: observation among adults with hydrolyzed wheat protein allergy2019

    • Author(s)
      Fukutomi Yuma、Teruuchi Yuya、Nakatani Eiji、Minami Takafumi、Sasagawa Yoshikiyo、Fukushima Masao、Kamide Yosuke、Sekiya Kiyoshi、Saito Hirohisa、Teshima Reiko、Adachi Reiko、Taniguchi Masami
    • Journal Title

      Allergy

      Volume: 印刷中 Issue: 8 Pages: 1584-1587

    • DOI

      10.1111/all.13866

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Updated 5-year survival and exploratory T x N subset analyses of ACTS-CC trial: a randomised controlled trial of S-1 versus tegafur-uracil/leucovorin as adjuvant chemotherapy for stage III colon cancer2018

    • Author(s)
      Kusumoto Tetsuya、Ishiguro Megumi、Nakatani Eiji、Yoshida Motoki、Inoue Tsukasa、Nakamoto Yoshihiko、Shiomi Akio、Takagane Akinori、Sunami Eiji、Shinozaki Hiroharu、Takii Yasumasa、Maeda Atsuyuki、Ojima Hitoshi、Hashida Hiroki、Mukaiya Mitsuhiro、Yokoyama Tadashi、Nakamura Masato、Munemoto Yoshinori、Sugihara Kenichi
    • Journal Title

      ESMO Open

      Volume: 3 Issue: 6 Pages: e000428-e000428

    • DOI

      10.1136/esmoopen-2018-000428

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical outcomes after tracheoplasty in patients with congenital tracheal stenosis in 1997?20142018

    • Author(s)
      Yokoi Akiko、Hasegawa Tomomi、Oshima Yoshihiro、Higashide Satoshi、Nakatani Eiji、Kaneda Hideaki、Kawamoto Atsuhiko、Nishijima Eiji
    • Journal Title

      Journal of pediatric surgery

      Volume: 印刷中 Issue: 11 Pages: 2140-2144

    • DOI

      10.1016/j.jpedsurg.2017.12.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Portal congestion and intestinal edema in hospitalized patients with heart failure2017

    • Author(s)
      Ikeda Yuki、Ishii Shunsuke、Yazaki Mayu、Fujita Teppei、Iida Yuichiro、Kaida Toyoji、Nabeta Takeru、Nakatani Eiji、Maekawa Emi、Yanagisawa Tomoyoshi、Koitabashi Toshimi、Inomata Takayuki、Ako Junya
    • Journal Title

      Heart and Vessels

      Volume: 33 Issue: 7 Pages: 740

    • DOI

      10.1007/s00380-018-1117-5

    • URL

      https://pure.teikyo.jp/en/publications/4f23052b-4031-4537-9489-df351dea9765

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A 5-year multicenter prospective cohort study on the long-term visual prognosis and predictive factors for visual outcome in Japanese patients with age-related macular degeneration: the AMD2000 study2017

    • Author(s)
      Akagi-Kurashige Yumiko、AMD2000 study group、Tsujikawa Akitaka、Yuzawa Mitsuko、Ishibashi Tatsuro、Nakanishi Hideo、Nakatani Eiji、Teramukai Satoshi、Fukushima Masanori、Yoshimura Nagahisa
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 62 Issue: 2 Pages: 137-143

    • DOI

      10.1007/s10384-017-0554-5

    • NAID

      210000173631

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Relaxing the Interaction Test in the Cox Proportional Hazard Model on Epidemiological Studies2020

    • Author(s)
      Nakatani Eiji、Sato Yoko
    • Organizer
      Joint Statistical Meeting 2020, Virtual Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨粗鬆症に起因する大腿骨骨折の患者における死亡に関する予後因子の同定:大規模な静岡国保データベース(SKDB)の解析2020

    • Author(s)
      中谷 英仁、田中 清、佐藤 洋子、宮地 良樹
    • Organizer
      第22回日本骨粗鬆症学会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal subclassification via propensity scores using graphical presentations2019

    • Author(s)
      Eiji Nakatani
    • Organizer
      2019 Joint Statistical Meetings
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 静岡県の国民健康及び高齢者保険加入者における健診時項目からの 維持透析導入予測2019

    • Author(s)
      中谷英仁
    • Organizer
      公衆衛生学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Subgroup discovery analysis by new individual treatment effect in randomized trials2018

    • Author(s)
      Eiji Nakatani
    • Organizer
      XXIXth International Biometric Conference (29th IBC)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 臨床試験データにおける新しい個別治療効果を用いたサブグループ探索解析2018

    • Author(s)
      中谷 英仁
    • Organizer
      第3回 統計・機械学習若手シンポジウム「統計・機械学習の交わりと拡がり
    • Related Report
      2018 Research-status Report
  • [Remarks] リスク予測モデルWebサイト

    • URL

      https://s-pred.jp/

    • Related Report
      2020 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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